MC1R cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC1R
Entrez Gene ID	281298
Full Name	melanocortin 1 receptor
Synonyms	MC1-R,MSHR
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174108.2	NP_776533.1	melanocyte-stimulating hormone receptor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MC1R	NP_002377.4
Bos taurus (cattle)	MC1R	NP_776533.1
Pan troglodytes (chimpanzee)	MC1R	NP_001009152.1
Mus musculus (house mouse)	Mc1r	NP_032585.2
Canis lupus familiaris (dog)	MC1R	NP_001014304.1
Rattus norvegicus (Norway rat)	Mc1r	XP_006255857.1
Xenopus tropicalis (tropical clawed frog)	mc1r	XP_002937630.2
Gallus gallus (chicken)	MC1R	NP_001026633.1
Danio rerio (zebrafish)	mc1r	NP_851301.1

Gene Ontology
Bibliography

Related articles in PubMed

New variants in the melanocortin 1 receptor gene (MC1R) in Asian cattle.
Zhang Y, Li Q, Ye S, Faruque MO, Yu Y, Sun D, Zhang S, Wang Y
Animal genetics45(4)609-10(2014 Aug)

Identification of a major locus interacting with MC1R and modifying black coat color in an F? Nellore-Angus population.
Hanna LL, Sanders JO, Riley DG, Abbey CA, Gill CA
Genetics, selection, evolution : GSE464(2014 Jan)

Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle.
Schmutz SM, Dreger DL
Animal genetics44(1)9-13(2013 Feb)

Isolation and characteristics of the melanocortin 1 receptor gene (MC1R) in the Chinese yakow (Bos grunniens?Bos taurus).
Xi D, Wu M, Fan Y, Huo Y, Leng J, Gou X, Mao H, Deng W
Gene498(2)259-63(2012 May)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The e and E+ are the main MC1R haplotypes in taurine or intermediate breeds from China. The haplotypes defined by c.416C>T, c.583C>T and c.890T>C, found mostly in China and Bangladesh, are the typical haplotypes of Bos indicus.
Title: New variants in the melanocortin 1 receptor gene (MC1R) in Asian cattle.

Recombinants in a 5 Mb region surrounding the cluster of tyrosine kinase receptor genes implicated PDGFRA as the strongest positional candidate gene interacting with MC1R and modifying black coat color in an F Nellore-Angus population.
Title: Identification of a major locus interacting with MC1R and modifying black coat color in an F? Nellore-Angus population.

Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL genes.
Title: Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle.

the relationship of polymorphism of the MC1R with coat colour
Title: Isolation and characteristics of the melanocortin 1 receptor gene (MC1R) in the Chinese yakow (Bos grunniens?Bos taurus).

Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
Title: Molecular variation in pigmentation genes contributing to coat colour in native Korean Hanwoo cattle.

The following MC1R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC1R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41726	NM_174108.2 Latest version!	Bos taurus melanocortin 1 receptor (MC1R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC1R ( NM_174108.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776533.1 Bos taurus melanocortin 1 receptor (MC1R), mRNA.

Price & Availability↑

CloneID	OBa41726
Clone ID Related Accession (Same CDS sequence)	NM_174108.2
Accession Version	NM_174108.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	melanocyte-stimulating hormone receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF445642.1. On Jun 3, 2003 this sequence version replaced NM_174108.1. ##Evidence-Data-START## Transcript exon combination :: AF445642.1 [ECO:0000332] ##Evidence-Data-END##

ATGCCTGCAC TTGGCTCCCA GAGGCGGCTG CTGGGTTCCC TTAACTGCAC GCCCCCAGCC 
ACCCTCCCCT TCACCCTGGC CCCCAACCGG ACGGGGCCCC AGTGCCTGGA GGTGTCCATC 
CCTGACGGGC TCTTTCTCAG CCTGGGGCTG GTGAGTCTCG TGGAGAACGT GCTGGTAGTG 
GCTGCCATTG CCAAGAACCG CAACCTGCAC TCCCCCATGT ACTACTTTAT CTGCTGCCTG 
GCTGTGTCTG ACTTGCTGGT GAGCGTCAGC AACGTGCTGG AGACGGCAGT CATGCCGCTG 
CTGGAGGCCG GTGTCCTGGC CACCCAGGCG GCCGTGGTGC AGCAGCTGGA CAATGTCATC 
GACGTGCTCA TCTGCGGATC CATGGTGTCC AGCCTCTGCT TCCTGGGTGC CATTGCTGTG 
GACCGCTACA TCTCCATCTT CTACGCCCTG CGGTACCACA GTGTTGTGAC ACTGCCCCGA 
GCGTGGAGGA TCATTGCGGC CATCTGGGTG GCCAGCATCC TCACCAGCCT GCTCTTCATC 
ACCTACTACA ACCACAAGGT CATCCTGCTG TGCCTCGTTG GCCTCTTCAT AGCTATGCTG 
GCCCTGATGG CCGTCCTCTA CGTCCACATG CTGGCCCGGG CCTGCCAGCA TGCCCGGGGC 
ATTGCCCGGC TCCAGAAGAG GCAGCGCCCC ATTCATCAGG GCTTTGGCCT CAAGGGCGCT 
GCCAACCTCA CCATCCTGCT GGGCGTCTTC TTCCTCTGCT GGGGCCCCTT CTTCCTGCAC 
CTCTCGCTCA TCGTCCTCTG CCCCCAGCAC CCCACCTGTG GCTGCATCTT CAAGAACTTC 
AACCTCTTCC TGGCCCTCAT CATTTGCAAC GCCATTGTGG ACCCCCTCAT CTATGCCTTC 
CGCAGCCAGG AGCTCCGGAA GACGCTCCAA GAGGTGCTGC AGTGCTCCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776533.1
CDS	284..1237
Translation	MPALGSQRRLLGSLNCTPPATLPFTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMPLLEAGVLATQAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSLLFITYYNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHARGIARLQKRQRPIHQGFGLKGAANLTILLGVFFLCWGPFFLHLSLIVLCPQHPTCGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW

Target ORF information:

RefSeq Version	NM_174108.2
Organism	Bos taurus(cattle)
Definition	Bos taurus melanocortin 1 receptor (MC1R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174108.2

ORF Insert Sequence:

ATGCCTGCAC TTGGCTCCCA GAGGCGGCTG CTGGGTTCCC TTAACTGCAC GCCCCCAGCC 
ACCCTCCCCT TCACCCTGGC CCCCAACCGG ACGGGGCCCC AGTGCCTGGA GGTGTCCATC 
CCTGACGGGC TCTTTCTCAG CCTGGGGCTG GTGAGTCTCG TGGAGAACGT GCTGGTAGTG 
GCTGCCATTG CCAAGAACCG CAACCTGCAC TCCCCCATGT ACTACTTTAT CTGCTGCCTG 
GCTGTGTCTG ACTTGCTGGT GAGCGTCAGC AACGTGCTGG AGACGGCAGT CATGCCGCTG 
CTGGAGGCCG GTGTCCTGGC CACCCAGGCG GCCGTGGTGC AGCAGCTGGA CAATGTCATC 
GACGTGCTCA TCTGCGGATC CATGGTGTCC AGCCTCTGCT TCCTGGGTGC CATTGCTGTG 
GACCGCTACA TCTCCATCTT CTACGCCCTG CGGTACCACA GTGTTGTGAC ACTGCCCCGA 
GCGTGGAGGA TCATTGCGGC CATCTGGGTG GCCAGCATCC TCACCAGCCT GCTCTTCATC 
ACCTACTACA ACCACAAGGT CATCCTGCTG TGCCTCGTTG GCCTCTTCAT AGCTATGCTG 
GCCCTGATGG CCGTCCTCTA CGTCCACATG CTGGCCCGGG CCTGCCAGCA TGCCCGGGGC 
ATTGCCCGGC TCCAGAAGAG GCAGCGCCCC ATTCATCAGG GCTTTGGCCT CAAGGGCGCT 
GCCAACCTCA CCATCCTGCT GGGCGTCTTC TTCCTCTGCT GGGGCCCCTT CTTCCTGCAC 
CTCTCGCTCA TCGTCCTCTG CCCCCAGCAC CCCACCTGTG GCTGCATCTT CAAGAACTTC 
AACCTCTTCC TGGCCCTCAT CATTTGCAAC GCCATTGTGG ACCCCCTCAT CTATGCCTTC 
CGCAGCCAGG AGCTCCGGAA GACGCTCCAA GAGGTGCTGC AGTGCTCCTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New variants in the melanocortin 1 receptor gene (MC1R) in Asian cattle.
Animal genetics45(4)609-10(2014 Aug)
Zhang Y,Li Q,Ye S,Faruque MO,Yu Y,Sun D,Zhang S,Wang Y

Identification of a major locus interacting with MC1R and modifying black coat color in an F? Nellore-Angus population.
Genetics, selection, evolution : GSE464(2014 Jan)
Hanna LL,Sanders JO,Riley DG,Abbey CA,Gill CA

Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle.
Animal genetics44(1)9-13(2013 Feb)
Schmutz SM,Dreger DL

Isolation and characteristics of the melanocortin 1 receptor gene (MC1R) in the Chinese yakow (Bos grunniens?Bos taurus).
Gene498(2)259-63(2012 May)
Xi D,Wu M,Fan Y,Huo Y,Leng J,Gou X,Mao H,Deng W

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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MC1R cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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