IL2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL2
Entrez Gene ID	280822
Full Name	interleukin 2
Synonyms	IL-2,TCGF
General protein information	Preferred Names interleukin 2 Names interleukin-2 T-cell growth factor interleukin2
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024976996.1	XP_024832764.1	interleukin-2 isoform X1
NM_180997.2	NP_851340.2	interleukin-2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Detecting the effects of selection at the population level in six bovine immune genes.
Freeman AR, Lynn DJ, Murray C, Bradley DG
BMC genetics962(2008 Oct)

Functional analysis of a single nucleotide polymorphism in a potential binding site for GATA transcription factors in the ovine interleukin 2 gene.
L?hken G, Stamm I, Menge C, Erhardt G
Veterinary immunology and immunopathology107(1-2)51-6(2005 Aug)

Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.
Yamanaka H, Hagiwara K, Kirisawa R, Iwai H
Microbiology and immunology47(6)461-8(2003)

Cloning, sequence, and expression of bovine interleukin 2.
Cerretti DP, McKereghan K, Larsen A, Cantrell MA, Anderson D, Gillis S, Cosman D, Baker PE
Proceedings of the National Academy of Sciences of the United States of America83(10)3223-7(1986 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
Title: Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.

The following IL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44972	NM_180997.2 Latest version!	Bos taurus interleukin 2 (IL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OBa44972	XM_024976996.1 Latest version!	Bos taurus interleukin 2 (IL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL2 ( NM_180997.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_851340.2 Bos taurus interleukin 2 (IL2), mRNA.

Price & Availability↑

CloneID	OBa44972
Clone ID Related Accession (Same CDS sequence)	XM_024976996.1 , NM_180997.2
Accession Version	NM_180997.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	interleukin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FE004067.1, M12791.1, CB458801.1 and FE016063.1. On Mar 10, 2012 this sequence version replaced NM_180997.1. ##Evidence-Data-START## Transcript exon combination :: FE004067.1, M12791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145426, SAMN03145442 [ECO:0000348] ##Evidence-Data-END##

ATGTACAAGA TACAACTCTT GTCTTGCATT GCACTAACTC TTGCACTCGT TGCAAACGGT 
GCACCTACTT CAAGCTCTAC GGGGAACACA ATGAAAGAAG TGAAGTCATT GCTGCTGGAT 
TTACAGTTGC TTTTGGAGAA AGTTAAAAAT CCTGAGAACC TCAAGCTCTC CAGGATGCAT 
ACATTTGACT TTTACGTGCC CAAGGTTAAC GCTACAGAAT TGAAACATCT TAAGTGTTTA 
CTAGAAGAAC TCAAACTTCT AGAGGAAGTG CTAAATTTAG CTCCAAGCAA AAACCTGAAC 
CCCAGAGAGA TCAAGGATTC AATGGACAAT ATCAAGAGAA TCGTTTTGGA ACTACAGGGA 
TCTGAAACAA GATTCACATG TGAATATGAT GATGCAACAG TAAACGCTGT AGAATTTCTG 
AACAAATGGA TTACCTTTTG TCAAAGCATC TACTCAACAA TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851340.2
CDS	48..515
Translation	MYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFDFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETRFTCEYDDATVNAVEFLNKWITFCQSIYSTMT

Target ORF information:

RefSeq Version	NM_180997.2
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 (IL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_180997.2

ORF Insert Sequence:

ATGTACAAGA TACAACTCTT GTCTTGCATT GCACTAACTC TTGCACTCGT TGCAAACGGT 
GCACCTACTT CAAGCTCTAC GGGGAACACA ATGAAAGAAG TGAAGTCATT GCTGCTGGAT 
TTACAGTTGC TTTTGGAGAA AGTTAAAAAT CCTGAGAACC TCAAGCTCTC CAGGATGCAT 
ACATTTGACT TTTACGTGCC CAAGGTTAAC GCTACAGAAT TGAAACATCT TAAGTGTTTA 
CTAGAAGAAC TCAAACTTCT AGAGGAAGTG CTAAATTTAG CTCCAAGCAA AAACCTGAAC 
CCCAGAGAGA TCAAGGATTC AATGGACAAT ATCAAGAGAA TCGTTTTGGA ACTACAGGGA 
TCTGAAACAA GATTCACATG TGAATATGAT GATGCAACAG TAAACGCTGT AGAATTTCTG 
AACAAATGGA TTACCTTTTG TCAAAGCATC TACTCAACAA TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2 ( XM_024976996.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024832764.1 Bos taurus interleukin 2 (IL2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa44972
Clone ID Related Accession (Same CDS sequence)	XM_024976996.1 , NM_180997.2
Accession Version	XM_024976996.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	interleukin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037344.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACAAGA TACAACTCTT GTCTTGCATT GCACTAACTC TTGCACTCGT TGCAAACGGT 
GCACCTACTT CAAGCTCTAC GGGGAACACA ATGAAAGAAG TGAAGTCATT GCTGCTGGAT 
TTACAGTTGC TTTTGGAGAA AGTTAAAAAT CCTGAGAACC TCAAGCTCTC CAGGATGCAT 
ACATTTGACT TTTACGTGCC CAAGGTTAAC GCTACAGAAT TGAAACATCT TAAGTGTTTA 
CTAGAAGAAC TCAAACTTCT AGAGGAAGTG CTAAATTTAG CTCCAAGCAA AAACCTGAAC 
CCCAGAGAGA TCAAGGATTC AATGGACAAT ATCAAGAGAA TCGTTTTGGA ACTACAGGGA 
TCTGAAACAA GATTCACATG TGAATATGAT GATGCAACAG TAAACGCTGT AGAATTTCTG 
AACAAATGGA TTACCTTTTG TCAAAGCATC TACTCAACAA TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024832764.1
CDS	303..770
Translation	MYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFDFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETRFTCEYDDATVNAVEFLNKWITFCQSIYSTMT

Target ORF information:

RefSeq Version	XM_024976996.1
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 2 (IL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024976996.1

ORF Insert Sequence:

ATGTACAAGA TACAACTCTT GTCTTGCATT GCACTAACTC TTGCACTCGT TGCAAACGGT 
GCACCTACTT CAAGCTCTAC GGGGAACACA ATGAAAGAAG TGAAGTCATT GCTGCTGGAT 
TTACAGTTGC TTTTGGAGAA AGTTAAAAAT CCTGAGAACC TCAAGCTCTC CAGGATGCAT 
ACATTTGACT TTTACGTGCC CAAGGTTAAC GCTACAGAAT TGAAACATCT TAAGTGTTTA 
CTAGAAGAAC TCAAACTTCT AGAGGAAGTG CTAAATTTAG CTCCAAGCAA AAACCTGAAC 
CCCAGAGAGA TCAAGGATTC AATGGACAAT ATCAAGAGAA TCGTTTTGGA ACTACAGGGA 
TCTGAAACAA GATTCACATG TGAATATGAT GATGCAACAG TAAACGCTGT AGAATTTCTG 
AACAAATGGA TTACCTTTTG TCAAAGCATC TACTCAACAA TGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Detecting the effects of selection at the population level in six bovine immune genes.
BMC genetics962(2008 Oct)
Freeman AR,Lynn DJ,Murray C,Bradley DG

Functional analysis of a single nucleotide polymorphism in a potential binding site for GATA transcription factors in the ovine interleukin 2 gene.
Veterinary immunology and immunopathology107(1-2)51-6(2005 Aug)
L?hken G,Stamm I,Menge C,Erhardt G

Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression.
Microbiology and immunology47(6)461-8(2003)
Yamanaka H,Hagiwara K,Kirisawa R,Iwai H

Cloning, sequence, and expression of bovine interleukin 2.
Proceedings of the National Academy of Sciences of the United States of America83(10)3223-7(1986 May)
Cerretti DP,McKereghan K,Larsen A,Cantrell MA,Anderson D,Gillis S,Cosman D,Baker PE

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IL2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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