GHR cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	GHR
Entrez Gene ID	280805
Full Name	growth hormone receptor
General protein information	Preferred Names growth hormone receptor Names growth hormone receptor GH receptor somatotropin receptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Genome	Chromosome: 20 Map Location: 20q17

mRNA and Protein(s)

mRNA	Protein	Name
NM_176608.1	NP_788781.1	growth hormone receptor precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GHR	NP_788781.1
Mus musculus (house mouse)	Ghr	NP_001273299.1
Gallus gallus (chicken)	GHR	NP_001001293.1
Danio rerio (zebrafish)	ghra	NP_001077047.1
Homo sapiens (human)	GHR	NP_001229328.1
	GHR	NP_001036132.1
Rattus norvegicus (Norway rat)	Ghr	NP_058790.1
Pan troglodytes (chimpanzee)	GHR	XP_003950612.1
Canis lupus familiaris (dog)	GHR	NP_001003123.1
Xenopus tropicalis (tropical clawed frog)	ghr	XP_002933093.2

Gene Ontology
Bibliography

Related articles in PubMed

Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows.
Hax LT, Schneider A, Jacometo CB, Mattei P, da Silva TC, Farina G, Corr?a MN
Theriogenology8867-72(2017 Jan)

The somatotropic axis during the physiological estrus cycle in dairy heifers--Effect on hepatic expression of GHR and SOCS2.
Mense K, Meyerholz M, Gil Araujo M, Lietzau M, Knaack H, Wrenzycki C, Hoedemaker M, Piechotta M
Journal of dairy science98(4)2409-18(2015 Apr)

Comparative Study on the Genetic Diversity of GHR Gene in Tibetan Cattle and Holstein Cows.
Deng F, Xia C, Jia X, Song T, Liu J, Lai SJ, Chen SY
Animal biotechnology26(3)217-21(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Title: Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows.

hepatic growth hormone receptor and suppressor of cytokine signaling (SOCS)2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
Title: The somatotropic axis during the physiological estrus cycle in dairy heifers--Effect on hepatic expression of GHR and SOCS2.

Comparatively studied genetic diversity of growth hormone receptor (GHR) in Tibetan cattle and Chinese Holstein cow.
Title: Comparative Study on the Genetic Diversity of GHR Gene in Tibetan Cattle and Holstein Cows.

This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality.
Title: ?-Calpain, calpastatin, and growth hormone receptor genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in Angus cattle selected to increase minor haplotype and allele frequencies.

the data support the high potential of the growth hormone receptor F279Y polymorphism as a marker for the improvement of milk traits in selection programs
Title: The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in German Holstein dairy cattle.

The following GHR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GHR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43613	NM_176608.1 Latest version!	Bos taurus growth hormone receptor (GHR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GHR ( NM_176608.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_788781.1 Bos taurus growth hormone receptor (GHR), mRNA.

Price & Availability↑

CloneID	OBa43613
Clone ID Related Accession (Same CDS sequence)	NM_176608.1
Accession Version	NM_176608.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	growth hormone receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF044258.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF044258.1, X70041.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGGATCTCT GGCAGCTGCT GTTGACCTTG GCAGTGGCAG GCTCCAGTGA TGCTTTTTCT 
GGGAGTGAAG CCACACCAGC TTTCCTTGTC AGAGCATCTC AGAGTCTGCA GATACTATAT 
CCAGTCCTAG AGACAAATTC TTCTGGGAAT CCTAAATTCA CCAAGTGCCG TTCACCTGAA 
CTGGAGACTT TCTCATGTCA CTGGACAGAT GGGGCTAATC ACAGTTTACA GAGCCCAGGA 
TCTGTACAGA TGTTCTATAT CAGAAGGGAC ATTCAAGAAT GGAAAGAATG CCCCGATTAC 
GTCTCTGCTG GTGAAAACAG CTGTTACTTT AATTCGTCTT ATACCTCTGT GTGGACCCCC 
TACTGCATCA AGCTAACTAG CAATGGCGGT ATTGTGGATC ATAAGTGTTT CTCTGTTGAG 
GACATAGTAC AACCAGATCC ACCCGTTGGC CTCAACTGGA CTCTACTGAA CATCAGTTTG 
ACAGAGATTC ATGCCGACAT CCTAGTGAAA TGGGAACCAC CACCCAATAC AGATGTTAAG 
ATGGGATGGA TAATCCTGGA GTATGAACTG CACTATAAAG AACTAAATGA GACCCAGTGG 
AAAATGATGG ACCCTTTAAT GGTAACATCA GTTCCGATGT ACTCGTTGAG ACTGGATAAA 
GAGTATGAAG TGCGTGTGAG AACCAGACAA CGAAACACTG AAAAATATGG CAAGTTCAGT 
GAGGTGCTCC TGATAACATT TCCTCAGATG AACCCATCTG CATGTGAAGA AGATTTCCAG 
TTTCCATGGT TCTTAATTAT TATCTTTGGA ATACTTGGGC TAGCAGTGAC ATTATATTTA 
CTCATATTTT CTAAACAGCA AAGGATTAAG ATGCTGATTC TACCCCCAGT TCCAGTTCCA 
AAGATTAAAG GAATTGATCC AGATCTCCTC AAGGAAGGAA AATTAGAAGA GGTGAATACA 
ATCTTAGCCA TTCATGACAA CTATAAACAC GAATTCTACA ATGATGACTC TTGGGTTGAA 
TTTATTGAAC TAGATATTGA TGACCCTGAT GAAAAGACTG AAGGGTCAGA CACAGACAGA 
CTTCTGAGCA ATGACCATGA AAAATCACTC AATATCTTTG GGGCAAAGGA TGACGACTCT 
GGGCGTACCA GCTGCTATGA ACCTGACATT CTGGAGGCTG ATTTCCATGT CAGTGACATG 
TGCGATGGTA CCTCAGAGGT TGCTCAGCCA CAAAGGTTAA AAGGGGAAGC AGATATCTCA 
TGCCTTGATC AGAAGAATCA AAATAATTCA CCTTCTAATG ATGCTGCCCC TGCTAGCCAG 
CAGCCCAGTG TTATCCTAGT AGAGGAAAAC AAACCAAGAC CACTTCTCAT TGGTGGAACT 
GAGTCAACTC ATCAAGCTGT CCATACACAG CTCAGCAATC CAAGTTCATT GGCAAACATT 
GATTTTTATG CCCAGGTAAG CGACATTACA CCAGCAGGAA ATGTGGTCCT TTCCCCAGGC 
CAAAAGAATA AGACTGGGAA CCCCCAGTGT GACACGCACC CAGAAGTGGT CACACCCTGC 
CAAGCTAACT TCATCGTGGA CAACGCTTAC TTCTGCGAGG TAGACGCCAA AAAGTACATT 
GCCCTGGCCC CTCATGTCGA GGCTGAATCA CACATAGAGC CAAGCTTTAA CCAGGAAGAC 
ATTTACATCA CCACAGAAAG CCTTACCACT ACAGCTGGGA GGTCGGGGAC AGCAGAACAT 
GTTCCAAGTT CTGAGATACC TGTCCCAGAT TATACCTCCA TTCATATAGT ACAGTCTCCA 
CAGGGCCTCG TACTCAATGC GACTGCCCTG CCCTTGCCTG ACAAAGAGTT TCTCTCATCA 
TGTGGCTATG TGAGCACAGA CCAACTGAAC AAAATCATGC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_788781.1
CDS	38..1942
Translation	MDLWQLLLTLAVAGSSDAFSGSEATPAFLVRASQSLQILYPVLETNSSGNPKFTKCRSPELETFSCHWTDGANHSLQSPGSVQMFYIRRDIQEWKECPDYVSAGENSCYFNSSYTSVWTPYCIKLTSNGGIVDHKCFSVEDIVQPDPPVGLNWTLLNISLTEIHADILVKWEPPPNTDVKMGWIILEYELHYKELNETQWKMMDPLMVTSVPMYSLRLDKEYEVRVRTRQRNTEKYGKFSEVLLITFPQMNPSACEEDFQFPWFLIIIFGILGLAVTLYLLIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDNYKHEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHEKSLNIFGAKDDDSGRTSCYEPDILEADFHVSDMCDGTSEVAQPQRLKGEADISCLDQKNQNNSPSNDAAPASQQPSVILVEENKPRPLLIGGTESTHQAVHTQLSNPSSLANIDFYAQVSDITPAGNVVLSPGQKNKTGNPQCDTHPEVVTPCQANFIVDNAYFCEVDAKKYIALAPHVEAESHIEPSFNQEDIYITTESLTTTAGRSGTAEHVPSSEIPVPDYTSIHIVQSPQGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP

Target ORF information:

RefSeq Version	NM_176608.1
Organism	Bos taurus(cattle)
Definition	Bos taurus growth hormone receptor (GHR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176608.1

ORF Insert Sequence:

ATGGATCTCT GGCAGCTGCT GTTGACCTTG GCAGTGGCAG GCTCCAGTGA TGCTTTTTCT 
GGGAGTGAAG CCACACCAGC TTTCCTTGTC AGAGCATCTC AGAGTCTGCA GATACTATAT 
CCAGTCCTAG AGACAAATTC TTCTGGGAAT CCTAAATTCA CCAAGTGCCG TTCACCTGAA 
CTGGAGACTT TCTCATGTCA CTGGACAGAT GGGGCTAATC ACAGTTTACA GAGCCCAGGA 
TCTGTACAGA TGTTCTATAT CAGAAGGGAC ATTCAAGAAT GGAAAGAATG CCCCGATTAC 
GTCTCTGCTG GTGAAAACAG CTGTTACTTT AATTCGTCTT ATACCTCTGT GTGGACCCCC 
TACTGCATCA AGCTAACTAG CAATGGCGGT ATTGTGGATC ATAAGTGTTT CTCTGTTGAG 
GACATAGTAC AACCAGATCC ACCCGTTGGC CTCAACTGGA CTCTACTGAA CATCAGTTTG 
ACAGAGATTC ATGCCGACAT CCTAGTGAAA TGGGAACCAC CACCCAATAC AGATGTTAAG 
ATGGGATGGA TAATCCTGGA GTATGAACTG CACTATAAAG AACTAAATGA GACCCAGTGG 
AAAATGATGG ACCCTTTAAT GGTAACATCA GTTCCGATGT ACTCGTTGAG ACTGGATAAA 
GAGTATGAAG TGCGTGTGAG AACCAGACAA CGAAACACTG AAAAATATGG CAAGTTCAGT 
GAGGTGCTCC TGATAACATT TCCTCAGATG AACCCATCTG CATGTGAAGA AGATTTCCAG 
TTTCCATGGT TCTTAATTAT TATCTTTGGA ATACTTGGGC TAGCAGTGAC ATTATATTTA 
CTCATATTTT CTAAACAGCA AAGGATTAAG ATGCTGATTC TACCCCCAGT TCCAGTTCCA 
AAGATTAAAG GAATTGATCC AGATCTCCTC AAGGAAGGAA AATTAGAAGA GGTGAATACA 
ATCTTAGCCA TTCATGACAA CTATAAACAC GAATTCTACA ATGATGACTC TTGGGTTGAA 
TTTATTGAAC TAGATATTGA TGACCCTGAT GAAAAGACTG AAGGGTCAGA CACAGACAGA 
CTTCTGAGCA ATGACCATGA AAAATCACTC AATATCTTTG GGGCAAAGGA TGACGACTCT 
GGGCGTACCA GCTGCTATGA ACCTGACATT CTGGAGGCTG ATTTCCATGT CAGTGACATG 
TGCGATGGTA CCTCAGAGGT TGCTCAGCCA CAAAGGTTAA AAGGGGAAGC AGATATCTCA 
TGCCTTGATC AGAAGAATCA AAATAATTCA CCTTCTAATG ATGCTGCCCC TGCTAGCCAG 
CAGCCCAGTG TTATCCTAGT AGAGGAAAAC AAACCAAGAC CACTTCTCAT TGGTGGAACT 
GAGTCAACTC ATCAAGCTGT CCATACACAG CTCAGCAATC CAAGTTCATT GGCAAACATT 
GATTTTTATG CCCAGGTAAG CGACATTACA CCAGCAGGAA ATGTGGTCCT TTCCCCAGGC 
CAAAAGAATA AGACTGGGAA CCCCCAGTGT GACACGCACC CAGAAGTGGT CACACCCTGC 
CAAGCTAACT TCATCGTGGA CAACGCTTAC TTCTGCGAGG TAGACGCCAA AAAGTACATT 
GCCCTGGCCC CTCATGTCGA GGCTGAATCA CACATAGAGC CAAGCTTTAA CCAGGAAGAC 
ATTTACATCA CCACAGAAAG CCTTACCACT ACAGCTGGGA GGTCGGGGAC AGCAGAACAT 
GTTCCAAGTT CTGAGATACC TGTCCCAGAT TATACCTCCA TTCATATAGT ACAGTCTCCA 
CAGGGCCTCG TACTCAATGC GACTGCCCTG CCCTTGCCTG ACAAAGAGTT TCTCTCATCA 
TGTGGCTATG TGAGCACAGA CCAACTGAAC AAAATCATGC CATAG