Gene Symbol | BRB |
Entrez Gene ID | 280720 |
Full Name | brain ribonuclease |
Synonyms | BRN |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » BRB cDNA ORF clone
Gene Symbol | BRB |
Entrez Gene ID | 280720 |
Full Name | brain ribonuclease |
Synonyms | BRN |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_024997226.1 | XP_024852994.1 | brain ribonuclease isoform X1 |
NM_173891.2 | NP_776316.1 | brain ribonuclease precursor |
Rattus norvegicus (Norway rat) | Rnase1l1 | NP_001013250.1 |
Canis lupus familiaris (dog) | LOC475395 | XP_003432057.1 |
Bos taurus (cattle) | RNASE1 | NP_001014408.2 |
Pan troglodytes (chimpanzee) | RNASE1 | NP_001009108.2 |
RNASE1 | NP_001038203.1 | |
Bos taurus (cattle) | BRB | NP_776316.1 |
Mus musculus (house mouse) | Rnase1 | NP_035401.2 |
Rattus norvegicus (Norway rat) | Rnase1 | NP_001025075.1 |
Homo sapiens (human) | RNASE1 | NP_937878.1 |
Rattus norvegicus (Norway rat) | Rnase1l2 | NP_001020287.1 |
Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs.
Dentis JL, Schreiber NB, Gilliam JN, Schutz LF, Spicer LJ
Domestic animal endocrinology5532-40(2016 Apr)
Bovine brain ribonuclease is the functional homolog of human ribonuclease 1.
Eller CH, Lomax JE, Raines RT
The Journal of biological chemistry289(38)25996-6006(2014 Sep)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family.
Pradeep L, Shin HC, Scheraga HA
FEBS letters580(21)5029-32(2006 Sep)
Cow milk angiogenin induces cytokine production in human blood leukocytes.
Shcheglovitova ON, Maksyanina EV, Ionova II, Rustam'yan YL, Komolova GS
Bulletin of experimental biology and medicine135(2)158-60(2003 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study concluded that brain ribonuclease (BRB) is a hormonally and developmentally regulated gene in bovine GCs and may regulate E2 production during follicular growth in cattle.
Title: Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs.
Brain ribonuclease, not RNase A, is the true bovine homolog of human RNase 1.
Title: Bovine brain ribonuclease is the functional homolog of human ribonuclease 1.
A direct correlation between the number of cis-prolyl bonds in a native protein and the complexity with which it folds is shown in the folding of three structurally homologous proteins of the ribonuclease family, namely RNase A, onconase and angiogenin.
Title: Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family.
Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes.
Title: Cow milk angiogenin induces cytokine production in human blood leukocytes.
The following BRB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BRB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa43308 | |
Clone ID Related Accession (Same CDS sequence) | NM_173891.2 | |
Accession Version | NM_173891.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | brain ribonuclease precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114791.1. On Apr 23, 2006 this sequence version replaced NM_173891.1. ##Evidence-Data-START## Transcript exon combination :: BC114791.1, EH200570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTCTGA AGTCCCTGGT CCTGTTGTCA CTGCTGGTCC TGGTGCTGCT GCTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776316.1 |
CDS | 72..575 |
Translation |
Target ORF information:
Target ORF information:
|
NM_173891.2 |
1 | ATGGCTCTGA AGTCCCTGGT CCTGTTGTCA CTGCTGGTCC TGGTGCTGCT GCTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa219378 | |
Clone ID Related Accession (Same CDS sequence) | XM_024997226.1 | |
Accession Version | XM_024997226.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | brain ribonuclease isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGA AGTCCCTGGT CCTGTTGTCA CTGCTGGTCC TGGTGCTGCT GCTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024852994.1 |
CDS | 133..636 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024997226.1 |
1 | ATGGCTCTGA AGTCCCTGGT CCTGTTGTCA CTGCTGGTCC TGGTGCTGCT GCTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs. |
Bovine brain ribonuclease is the functional homolog of human ribonuclease 1. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Correlation of folding kinetics with the number and isomerization states of prolines in three homologous proteins of the RNase family. |
Cow milk angiogenin induces cytokine production in human blood leukocytes. |