AT4G37190 cDNA ORF clone, Arabidopsis thaliana(thale cress)

The following AT4G37190 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AT4G37190 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OAb02117 NM_119882.3
Latest version!
Arabidopsis thaliana plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein (AT4G37190), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $342.30
$489.00
OAb02118 NM_001036723.2
Latest version!
Arabidopsis thaliana plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein (AT4G37190), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $342.30
$489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OAb02117
    Clone ID Related Accession (Same CDS sequence) NM_119882.3
    Accession Version NM_119882.3 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1689bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075). On Sep 12, 2016 this sequence version replaced NM_119882.2.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGAGAGAAA TTGTGACGAT TCAAGTTGGA GAATTCGCAA ACTTTGTTGG CTCTCACTTT 
    TGGAATTTCC AGGATGAATT GCTCGGATTG GCTAGTGACC CTGAAAGCGA TCCAATCTTT
    AGAAACCATA ATCTCGACAT GGATGTTCTC TACCGCTCCG GTGAGACCCA GCAGGGGGTT
    GCTACATACA CTCCTCGTTT GGTTTCAGTC AACTTAAAAG GGGCACTAGG GACCATGAGC
    TCACGCGGTA CACTTTACAA CGAAGGTTCT TCATCAAGAT CAGATTCTTC AGCAACCTGG
    TTTGGAGATG TTGATACTCA GAGATCTGAA CCTCGAAAGA GGAACTTGTT TCTGCAAAGT
    TTGTACGAGG AAGAACATGT AGTGGGGAAA GAAAAGGCGA AAGAGATTGA GGACAAAGAT
    ATTGTTGGAT GCTTAGATGA GGAAGTTGAA TGTTGGACTG ACTTCTCTAA ATCCCATTAT
    CATCCTCAAA GTTTATATGA ATTGAACGGA TTATGGATGG ACTCTCAGGC TTTTAACAAT
    TATGGAATTG GTAAAGACGT TTTCTCTGAG GCTTCACGTG GAGAGGAAAT ATGTGACAGA
    CTCCGTTTTT TCGTGGAAGA GTGTGATCAT ATTCAGGGTA TTAAGTTCCT AGTGGATGAT
    TCGGGAGGAT TTTCCGCTGT AGCAGCGGAT TTCCTTGAAA ACATGGCAGA TGAGTACACG
    AATGTACCTG TATTGCTATA TTCCGTAAGG ACTCCAATGT CACAGATGAG CTCGAAAAAG
    ACAGTTTCAA ACAAGCTTCA CGATGCGATA TCGTTTTCTC GACTCTCATC CTTTTGTAAA
    CTCTTCACTC CAATCGGTTT ACCATCTTTG ACAGGAAGTA AAGCATCAAA ATTTCTTAAT
    CTCGGTGATG AGAAACCTTA TCGAAGCAGT GCAGTGTACG CCGCTGCTCT ACATTCAAGC
    ACAATACCTT TCCGAATGCA ACCCACTAGC TCAGATTCAA GTGAAGTGTC AAATTCTATG
    GATGTTAATA CACTTGTACA GCTTTTAACG GGTCGTGGTA GACAAAACAT AGTGGCGATT
    TTAGATTCTG CAATGCCAGC TCCTACATTA GCAGGGAAGC AATTAGAGAA TACTCTTTTA
    ACGAGTTTGC AAGCACTAAC GCCGGAAGTA ACTGAAGATG TAGAAGACAA TCAAGCGGTT
    GAGTCAATGT GTATACTTGG AGCCCTTAGA TCAGAAGATA AAGAAGCATT GGTTTCAGAA
    GTGAAGAATG CGGTTGATGC ATCTTACGAA CAGGCAACCA CCAAAGGGAA ACCGTTGTTT
    TGCAATCTAT CGGTTTCGCG TTGTCCTCTT CCGGTACCAT TACCGTTTCC TTCTATATTT
    GGAAACCTTG TTGGGAGGAA AGGTGAGATA CTGAGCAGTC CAGTCTCGGA TTCTCTCTAC
    AGAGGCTCAC TAGATGTTCA CTCCATACCA GTAGCAACAA GATGGAGATC TTCAAGCGCA
    ATTTTGCCAT TTTTGGAAAC TAGAATGGGG AATTTAGAGA AACTTGGGAT CCAGTGGGGA
    GCCATGGGAT CAGATGTGGT TAGGGCCTGG GGATTTGGGA GAGAAGAATT GCAGGAAATG
    AGGGAGAATC TGTCAAAAAT GGTATCTGAG CTGAATCCTC AGTTTTTCGA ATCTTCGGAT
    TCAGATTAG

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_195436.1
    CDS152..1840
    Translation

    Target ORF information:

    RefSeq Version NM_119882.3
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein (AT4G37190), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_119882.3

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGAGAGAAA TTGTGACGAT TCAAGTTGGA GAATTCGCAA ACTTTGTTGG CTCTCACTTT 
    TGGAATTTCC AGGATGAATT GCTCGGATTG GCTAGTGACC CTGAAAGCGA TCCAATCTTT
    AGAAACCATA ATCTCGACAT GGATGTTCTC TACCGCTCCG GTGAGACCCA GCAGGGGGTT
    GCTACATACA CTCCTCGTTT GGTTTCAGTC AACTTAAAAG GGGCACTAGG GACCATGAGC
    TCACGCGGTA CACTTTACAA CGAAGGTTCT TCATCAAGAT CAGATTCTTC AGCAACCTGG
    TTTGGAGATG TTGATACTCA GAGATCTGAA CCTCGAAAGA GGAACTTGTT TCTGCAAAGT
    TTGTACGAGG AAGAACATGT AGTGGGGAAA GAAAAGGCGA AAGAGATTGA GGACAAAGAT
    ATTGTTGGAT GCTTAGATGA GGAAGTTGAA TGTTGGACTG ACTTCTCTAA ATCCCATTAT
    CATCCTCAAA GTTTATATGA ATTGAACGGA TTATGGATGG ACTCTCAGGC TTTTAACAAT
    TATGGAATTG GTAAAGACGT TTTCTCTGAG GCTTCACGTG GAGAGGAAAT ATGTGACAGA
    CTCCGTTTTT TCGTGGAAGA GTGTGATCAT ATTCAGGGTA TTAAGTTCCT AGTGGATGAT
    TCGGGAGGAT TTTCCGCTGT AGCAGCGGAT TTCCTTGAAA ACATGGCAGA TGAGTACACG
    AATGTACCTG TATTGCTATA TTCCGTAAGG ACTCCAATGT CACAGATGAG CTCGAAAAAG
    ACAGTTTCAA ACAAGCTTCA CGATGCGATA TCGTTTTCTC GACTCTCATC CTTTTGTAAA
    CTCTTCACTC CAATCGGTTT ACCATCTTTG ACAGGAAGTA AAGCATCAAA ATTTCTTAAT
    CTCGGTGATG AGAAACCTTA TCGAAGCAGT GCAGTGTACG CCGCTGCTCT ACATTCAAGC
    ACAATACCTT TCCGAATGCA ACCCACTAGC TCAGATTCAA GTGAAGTGTC AAATTCTATG
    GATGTTAATA CACTTGTACA GCTTTTAACG GGTCGTGGTA GACAAAACAT AGTGGCGATT
    TTAGATTCTG CAATGCCAGC TCCTACATTA GCAGGGAAGC AATTAGAGAA TACTCTTTTA
    ACGAGTTTGC AAGCACTAAC GCCGGAAGTA ACTGAAGATG TAGAAGACAA TCAAGCGGTT
    GAGTCAATGT GTATACTTGG AGCCCTTAGA TCAGAAGATA AAGAAGCATT GGTTTCAGAA
    GTGAAGAATG CGGTTGATGC ATCTTACGAA CAGGCAACCA CCAAAGGGAA ACCGTTGTTT
    TGCAATCTAT CGGTTTCGCG TTGTCCTCTT CCGGTACCAT TACCGTTTCC TTCTATATTT
    GGAAACCTTG TTGGGAGGAA AGGTGAGATA CTGAGCAGTC CAGTCTCGGA TTCTCTCTAC
    AGAGGCTCAC TAGATGTTCA CTCCATACCA GTAGCAACAA GATGGAGATC TTCAAGCGCA
    ATTTTGCCAT TTTTGGAAAC TAGAATGGGG AATTTAGAGA AACTTGGGAT CCAGTGGGGA
    GCCATGGGAT CAGATGTGGT TAGGGCCTGG GGATTTGGGA GAGAAGAATT GCAGGAAATG
    AGGGAGAATC TGTCAAAAAT GGTATCTGAG CTGAATCCTC AGTTTTTCGA ATCTTCGGAT
    TCAGATTAG

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OAb02118
    Clone ID Related Accession (Same CDS sequence) NM_001036723.2
    Accession Version NM_001036723.2 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1551bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075). On Apr 18, 2007 this sequence version replaced NM_001036723.1.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGGATGTTC TCTACCGCTC CGGTGAGACC CAGCAGGGGG TTGCTACATA CACTCCTCGT 
    TTGGTTTCAG TCAACTTAAA AGGGGCACTA GGGACCATGA GCTCACGCGG TACACTTTAC
    AACGAAGGTT CTTCATCAAG ATCAGATTCT TCAGCAACCT GGTTTGGAGA TGTTGATACT
    CAGAGATCTG AACCTCGAAA GAGGAACTTG TTTCTGCAAA GTTTGTACGA GGAAGAACAT
    GTAGTGGGGA AAGAAAAGGC GAAAGAGATT GAGGACAAAG ATATTGTTGG ATGCTTAGAT
    GAGGAAGTTG AATGTTGGAC TGACTTCTCT AAATCCCATT ATCATCCTCA AAGTTTATAT
    GAATTGAACG GATTATGGAT GGACTCTCAG GCTTTTAACA ATTATGGAAT TGGTAAAGAC
    GTTTTCTCTG AGGCTTCACG TGGAGAGGAA ATATGTGACA GACTCCGTTT TTTCGTGGAA
    GAGTGTGATC ATATTCAGGG TATTAAGTTC CTAGTGGATG ATTCGGGAGG ATTTTCCGCT
    GTAGCAGCGG ATTTCCTTGA AAACATGGCA GATGAGTACA CGAATGTACC TGTATTGCTA
    TATTCCGTAA GGACTCCAAT GTCACAGATG AGCTCGAAAA AGACAGTTTC AAACAAGCTT
    CACGATGCGA TATCGTTTTC TCGACTCTCA TCCTTTTGTA AACTCTTCAC TCCAATCGGT
    TTACCATCTT TGACAGGAAG TAAAGCATCA AAATTTCTTA ATCTCGGTGA TGAGAAACCT
    TATCGAAGCA GTGCAGTGTA CGCCGCTGCT CTACATTCAA GCACAATACC TTTCCGAATG
    CAACCCACTA GCTCAGATTC AAGTGAAGTG TCAAATTCTA TGGATGTTAA TACACTTGTA
    CAGCTTTTAA CGGGTCGTGG TAGACAAAAC ATAGTGGCGA TTTTAGATTC TGCAATGCCA
    GCTCCTACAT TAGCAGGGAA GCAATTAGAG AATACTCTTT TAACGAGTTT GCAAGCACTA
    ACGCCGGAAG TAACTGAAGA TGTAGAAGAC AATCAAGCGG TTGAGTCAAT GTGTATACTT
    GGAGCCCTTA GATCAGAAGA TAAAGAAGCA TTGGTTTCAG AAGTGAAGAA TGCGGTTGAT
    GCATCTTACG AACAGGCAAC CACCAAAGGG AAACCGTTGT TTTGCAATCT ATCGGTTTCG
    CGTTGTCCTC TTCCGGTACC ATTACCGTTT CCTTCTATAT TTGGAAACCT TGTTGGGAGG
    AAAGGTGAGA TACTGAGCAG TCCAGTCTCG GATTCTCTCT ACAGAGGCTC ACTAGATGTT
    CACTCCATAC CAGTAGCAAC AAGATGGAGA TCTTCAAGCG CAATTTTGCC ATTTTTGGAA
    ACTAGAATGG GGAATTTAGA GAAACTTGGG ATCCAGTGGG GAGCCATGGG ATCAGATGTG
    GTTAGGGCCT GGGGATTTGG GAGAGAAGAA TTGCAGGAAA TGAGGGAGAA TCTGTCAAAA
    ATGGTATCTG AGCTGAATCC TCAGTTTTTC GAATCTTCGG ATTCAGATTA G

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001031800.1
    CDS102..1652
    Translation

    Target ORF information:

    RefSeq Version NM_001036723.2
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein (AT4G37190), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001036723.2

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGGATGTTC TCTACCGCTC CGGTGAGACC CAGCAGGGGG TTGCTACATA CACTCCTCGT 
    TTGGTTTCAG TCAACTTAAA AGGGGCACTA GGGACCATGA GCTCACGCGG TACACTTTAC
    AACGAAGGTT CTTCATCAAG ATCAGATTCT TCAGCAACCT GGTTTGGAGA TGTTGATACT
    CAGAGATCTG AACCTCGAAA GAGGAACTTG TTTCTGCAAA GTTTGTACGA GGAAGAACAT
    GTAGTGGGGA AAGAAAAGGC GAAAGAGATT GAGGACAAAG ATATTGTTGG ATGCTTAGAT
    GAGGAAGTTG AATGTTGGAC TGACTTCTCT AAATCCCATT ATCATCCTCA AAGTTTATAT
    GAATTGAACG GATTATGGAT GGACTCTCAG GCTTTTAACA ATTATGGAAT TGGTAAAGAC
    GTTTTCTCTG AGGCTTCACG TGGAGAGGAA ATATGTGACA GACTCCGTTT TTTCGTGGAA
    GAGTGTGATC ATATTCAGGG TATTAAGTTC CTAGTGGATG ATTCGGGAGG ATTTTCCGCT
    GTAGCAGCGG ATTTCCTTGA AAACATGGCA GATGAGTACA CGAATGTACC TGTATTGCTA
    TATTCCGTAA GGACTCCAAT GTCACAGATG AGCTCGAAAA AGACAGTTTC AAACAAGCTT
    CACGATGCGA TATCGTTTTC TCGACTCTCA TCCTTTTGTA AACTCTTCAC TCCAATCGGT
    TTACCATCTT TGACAGGAAG TAAAGCATCA AAATTTCTTA ATCTCGGTGA TGAGAAACCT
    TATCGAAGCA GTGCAGTGTA CGCCGCTGCT CTACATTCAA GCACAATACC TTTCCGAATG
    CAACCCACTA GCTCAGATTC AAGTGAAGTG TCAAATTCTA TGGATGTTAA TACACTTGTA
    CAGCTTTTAA CGGGTCGTGG TAGACAAAAC ATAGTGGCGA TTTTAGATTC TGCAATGCCA
    GCTCCTACAT TAGCAGGGAA GCAATTAGAG AATACTCTTT TAACGAGTTT GCAAGCACTA
    ACGCCGGAAG TAACTGAAGA TGTAGAAGAC AATCAAGCGG TTGAGTCAAT GTGTATACTT
    GGAGCCCTTA GATCAGAAGA TAAAGAAGCA TTGGTTTCAG AAGTGAAGAA TGCGGTTGAT
    GCATCTTACG AACAGGCAAC CACCAAAGGG AAACCGTTGT TTTGCAATCT ATCGGTTTCG
    CGTTGTCCTC TTCCGGTACC ATTACCGTTT CCTTCTATAT TTGGAAACCT TGTTGGGAGG
    AAAGGTGAGA TACTGAGCAG TCCAGTCTCG GATTCTCTCT ACAGAGGCTC ACTAGATGTT
    CACTCCATAC CAGTAGCAAC AAGATGGAGA TCTTCAAGCG CAATTTTGCC ATTTTTGGAA
    ACTAGAATGG GGAATTTAGA GAAACTTGGG ATCCAGTGGG GAGCCATGGG ATCAGATGTG
    GTTAGGGCCT GGGGATTTGG GAGAGAAGAA TTGCAGGAAA TGAGGGAGAA TCTGTCAAAA
    ATGGTATCTG AGCTGAATCC TCAGTTTTTC GAATCTTCGG ATTCAGATTA G

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
    Nature402(6763)769-77(1999 Dec)
    Mayer K,Sch?ller C,Wambutt R,Murphy G,Volckaert G,Pohl T,D?sterh?ft A,Stiekema W,Entian KD,Terryn N,Harris B,Ansorge W,Brandt P,Grivell L,Rieger M,Weichselgartner M,de Simone V,Obermaier B,Mache R,M?ller M,Kreis M,Delseny M,Puigdomenech P,Watson M,Schmidtheini T,Reichert B,Portatelle D,Perez-Alonso M,Boutry M,Bancroft I,Vos P,Hoheisel J,Zimmermann W,Wedler H,Ridley P,Langham SA,McCullagh B,Bilham L,Robben J,Van der Schueren J,Grymonprez B,Chuang YJ,Vandenbussche F,Braeken M,Weltjens I,Voet M,Bastiaens I,Aert R,Defoor E,Weitzenegger T,Bothe G,Ramsperger U,Hilbert H,Braun M,Holzer E,Brandt A,Peters S,van Staveren M,Dirske W,Mooijman P,Klein Lankhorst R,Rose M,Hauf J,K?tter P,Berneiser S,Hempel S,Feldpausch M,Lamberth S,Van den Daele H,De Keyser A,Buysshaert C,Gielen J,Villarroel R,De Clercq R,Van Montagu M,Rogers J,Cronin A,Quail M,Bray-Allen S,Clark L,Doggett J,Hall S,Kay M,Lennard N,McLay K,Mayes R,Pettett A,Rajandream MA,Lyne M,Benes V,Rechmann S,Borkova D,Bl?cker H,Scharfe M,Grimm M,L?hnert TH,Dose S,de Haan M,Maarse A,Sch?fer M,M?ller-Auer S,Gabel C,Fuchs M,Fartmann B,Granderath K,Dauner D,Herzl A,Neumann S,Argiriou A,Vitale D,Liguori R,Piravandi E,Massenet O,Quigley F,Clabauld G,M?ndlein A,Felber R,Schnabl S,Hiller R,Schmidt W,Lecharny A,Aubourg S,Chefdor F,Cooke R,Berger C,Montfort A,Casacuberta E,Gibbons T,Weber N,Vandenbol M,Bargues M,Terol J,Torres A,Perez-Perez A,Purnelle B,Bent E,Johnson S,Tacon D,Jesse T,Heijnen L,Schwarz S,Scholler P,Heber S,Francs P,Bielke C,Frishman D,Haase D,Lemcke K,Mewes HW,Stocker S,Zaccaria P,Bevan M,Wilson RK,de la Bastide M,Habermann K,Parnell L,Dedhia N,Gnoj L,Schutz K,Huang E,Spiegel L,Sehkon M,Murray J,Sheet P,Cordes M,Abu-Threideh J,Stoneking T,Kalicki J,Graves T,Harmon G,Edwards J,Latreille P,Courtney L,Cloud J,Abbott A,Scott K,Johnson D,Minx P,Bentley D,Fulton B,Miller N,Greco T,Kemp K,Kramer J,Fulton L,Mardis E,Dante M,Pepin K,Hillier L,Nelson J,Spieth J,Ryan E,Andrews S,Geisel C,Layman D,Du H,Ali J,Berghoff A,Jones K,Drone K,Cotton M,Joshu C,Antonoiu B,Zidanic M,Strong C,Sun H,Lamar B,Yordan C,Ma P,Zhong J,Preston R,Vil D,Shekher M,Matero A,Shah R,Swaby IK,O'Shaughnessy A,Rodriguez M,Hoffmann J,Till S,Granat S,Shohdy N,Hasegawa A,Hameed A,Lodhi M,Johnson A,Chen E,Marra M,Martienssen R,McCombie WR