Gene Symbol | PLEKHA8 |
Entrez Gene ID | 482381 |
Full Name | pleckstrin homology domain containing A8 |
Synonyms | FAPP-2,FAPP2 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » PLEKHA8 cDNA ORF clone
Gene Symbol | PLEKHA8 |
Entrez Gene ID | 482381 |
Full Name | pleckstrin homology domain containing A8 |
Synonyms | FAPP-2,FAPP2 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_022427143.1 | XP_022282851.1 | pleckstrin homology domain-containing family A member 8 isoform X2 |
XM_022427144.1 | XP_022282852.1 | pleckstrin homology domain-containing family A member 8 isoform X3 |
XM_022427145.1 | XP_022282853.1 | pleckstrin homology domain-containing family A member 8 isoform X3 |
NM_001167698.1 | NP_001161170.1 | pleckstrin homology domain-containing family A member 8 |
XM_022427142.1 | XP_022282850.1 | pleckstrin homology domain-containing family A member 8 isoform X1 |
Canis lupus familiaris (dog) | PLEKHA8 | NP_001161170.1 |
Rattus norvegicus (Norway rat) | Plekha8 | NP_001102705.1 |
Xenopus tropicalis (tropical clawed frog) | plekha8 | XP_002932833.2 |
Bos taurus (cattle) | PLEKHA8 | NP_001183961.1 |
Danio rerio (zebrafish) | plekha8 | NP_001007375.1 |
Kluyveromyces lactis | KLLA0C14476g | XP_452848.1 |
Arabidopsis thaliana (thale cress) | GLTP1 | NP_973588.1 |
Homo sapiens (human) | PLEKHA8 | NP_001183955.1 |
Pan troglodytes (chimpanzee) | PLEKHA8 | NP_001186008.1 |
PLEKHA8 | XP_001086395.1 | |
Gallus gallus (chicken) | PLEKHA8 | XP_418736.3 |
Eremothecium gossypii | AGOS_ABL064W | NP_982883.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09396 | XP_003720215.1 |
Oryza sativa (rice) | Os02g0622400 | NP_001047468.1 |
Mus musculus (house mouse) | Plekha8 | NP_001157833.1 |
Neurospora crassa | NCU07947 | XP_962080.1 |
FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells.
Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S
American journal of physiology. Cell physiology297(6)C1389-96(2009 Dec)
Golgi protein FAPP2 tubulates membranes.
Cao X, Coskun U, R?ssle M, Buschhorn SB, Grzybek M, Dafforn TR, Lenoir M, Overduin M, Simons K
Proceedings of the National Academy of Sciences of the United States of America106(50)21121-5(2009 Dec)
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ 3rd, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abebe A, Abouelleil A, Aftuck L, Ait-Zahra M, Aldredge T, Allen N, An P, Anderson S, Antoine C, Arachchi H, Aslam A, Ayotte L, Bachantsang P, Barry A, Bayul T, Benamara M, Berlin A, Bessette D, Blitshteyn B, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Brown A, Cahill P, Calixte N, Camarata J, Cheshatsang Y, Chu J, Citroen M, Collymore A, Cooke P, Dawoe T, Daza R, Decktor K, DeGray S, Dhargay N, Dooley K, Dooley K, Dorje P, Dorjee K, Dorris L, Duffey N, Dupes A, Egbiremolen O, Elong R, Falk J, Farina A, Faro S, Ferguson D, Ferreira P, Fisher S, FitzGerald M, Foley K, Foley C, Franke A, Friedrich D, Gage D, Garber M, Gearin G, Giannoukos G, Goode T, Goyette A, Graham J, Grandbois E, Gyaltsen K, Hafez N, Hagopian D, Hagos B, Hall J, Healy C, Hegarty R, Honan T, Horn A, Houde N, Hughes L, Hunnicutt L, Husby M, Jester B, Jones C, Kamat A, Kanga B, Kells C, Khazanovich D, Kieu AC, Kisner P, Kumar M, Lance K, Landers T, Lara M, Lee W, Leger JP, Lennon N, Leuper L, LeVine S, Liu J, Liu X, Lokyitsang Y, Lokyitsang T, Lui A, Macdonald J, Major J, Marabella R, Maru K, Matthews C, McDonough S, Mehta T, Meldrim J, Melnikov A, Meneus L, Mihalev A, Mihova T, Miller K, Mittelman R, Mlenga V, Mulrain L, Munson G, Navidi A, Naylor J, Nguyen T, Nguyen N, Nguyen C, Nguyen T, Nicol R, Norbu N, Norbu C, Novod N, Nyima T, Olandt P, O'Neill B, O'Neill K, Osman S, Oyono L, Patti C, Perrin D, Phunkhang P, Pierre F, Priest M, Rachupka A, Raghuraman S, Rameau R, Ray V, Raymond C, Rege F, Rise C, Rogers J, Rogov P, Sahalie J, Settipalli S, Sharpe T, Shea T, Sheehan M, Sherpa N, Shi J, Shih D, Sloan J, Smith C, Sparrow T, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Stone S, Sykes S, Tchuinga P, Tenzing P, Tesfaye S, Thoulutsang D, Thoulutsang Y, Topham K, Topping I, Tsamla T, Vassiliev H, Venkataraman V, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Yang S, Yang X, Young G, Yu Q, Zainoun J, Zembek L, Zimmer A, Lander ES
Nature438(7069)803-19(2005 Dec)
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells.
Vieira OV, Verkade P, Manninen A, Simons K
The Journal of cell biology170(4)521-6(2005 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
purified FAPP2 protein has the capability to form tubules from membrane sheets in vitro. This activity is dependent on the phosphoinositide-binding activity of the PH domain of FAPP2
Title: Golgi protein FAPP2 tubulates membranes.
FAPP2 plays a specific role in apical transport in MDCK cells.
Title: FAPP2 is involved in the transport of apical cargo in polarized MDCK cells.
The following PLEKHA8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLEKHA8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00329 | |
Clone ID Related Accession (Same CDS sequence) | NM_001167698.1 | |
Accession Version | NM_001167698.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-21 | |
Organism | Canis lupus familiaris(dog) | |
Product | pleckstrin homology domain-containing family A member 8 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03009401.1 and AAEX03009402.1. On Nov 12, 2009 this sequence version replaced XM_539498.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: GU204956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGGGGG TGCTGTACAA GTGGACCAAC TATCTGAGCG GTTGGCAGCC TAGATGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001161170.1 |
CDS | 315..1874 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001167698.1 |
1 | ATGGAGGGGG TGCTGTACAA GTGGACCAAC TATCTGAGCG GTTGGCAGCC TAGATGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe293085 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427144.1 , XM_022427145.1 | |
Accession Version | XM_022427144.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | pleckstrin homology domain-containing family A member 8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGTCT GTGAAATTCA AGTTCATTCT GTAGATAACA CACGCATGGA CCTGATAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282852.1 |
CDS | 264..1688 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427144.1 |
1 | ATGGCGGTCT GTGAAATTCA AGTTCATTCT GTAGATAACA CACGCATGGA CCTGATAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe293085 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427144.1 , XM_022427145.1 | |
Accession Version | XM_022427145.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | pleckstrin homology domain-containing family A member 8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGTCT GTGAAATTCA AGTTCATTCT GTAGATAACA CACGCATGGA CCTGATAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282853.1 |
CDS | 246..1670 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427145.1 |
1 | ATGGCGGTCT GTGAAATTCA AGTTCATTCT GTAGATAACA CACGCATGGA CCTGATAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe293083 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427142.1 | |
Accession Version | XM_022427142.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | pleckstrin homology domain-containing family A member 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTATCCAG CTGAGGACAT TGACAAAACT TATGCAGAAA TAGTTAGAGA TGACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282850.1 |
CDS | 16..1674 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427142.1 |
1 | ATGTATCCAG CTGAGGACAT TGACAAAACT TATGCAGAAA TAGTTAGAGA TGACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe293084 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427143.1 | |
Accession Version | XM_022427143.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | pleckstrin homology domain-containing family A member 8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAAAGTT GGCAGCCTAG ATGGTTCCTA CTCTGTGGGG GTATATTATC CTATTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282851.1 |
CDS | 16..1542 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427143.1 |
1 | ATGCAAAGTT GGCAGCCTAG ATGGTTCCTA CTCTGTGGGG GTATATTATC CTATTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. |
Golgi protein FAPP2 tubulates membranes. |
Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. |