Gene Symbol | CYP3A12 |
Entrez Gene ID | 415129 |
Full Name | cytochrome P-450 3A12 |
Synonyms | CYPIIIA12,P450IIIA |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » CYP3A12 cDNA ORF clone
Gene Symbol | CYP3A12 |
Entrez Gene ID | 415129 |
Full Name | cytochrome P-450 3A12 |
Synonyms | CYPIIIA12,P450IIIA |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001003340.1 | NP_001003340.1 | cytochrome P450 3A12 |
Canis lupus familiaris (dog) | CYP3A26 | NP_001003338.1 |
Canis lupus familiaris (dog) | LOC489851 | XP_546969.2 |
Gallus gallus (chicken) | CYP3A4 | XP_414782.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012296 | XP_551896.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012292 | XP_001238280.1 |
Caenorhabditis elegans (roundworm) | cyp-25A2 | NP_497776.2 |
Bos taurus (cattle) | CYP3A5 | NP_001069356.1 |
Drosophila melanogaster (fruit fly) | Cyp9f2 | NP_650189.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100487846 | XP_002937898.2 |
Homo sapiens (human) | CYP3A4 | NP_059488.2 |
CYP3A4 | NP_001035504.1 | |
Canis lupus familiaris (dog) | CYP3A4 | XP_536868.2 |
Anopheles gambiae (African malaria mosquito) | CYP9L1 | XP_320243.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000818 | XP_316781.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012850 | XP_561320.5 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012293 | XP_001689238.1 |
Caenorhabditis elegans (roundworm) | cyp-25A3 | NP_001040850.1 |
Caenorhabditis elegans (roundworm) | cyp-25A4 | NP_497779.1 |
Caenorhabditis elegans (roundworm) | cyp-25A6 | NP_500512.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100487054 | XP_002937893.2 |
Canis lupus familiaris (dog) | CYP3A12 | NP_001003340.1 |
Caenorhabditis elegans (roundworm) | cyp-25A1 | NP_497775.3 |
Magnaporthe oryzae (rice blast fungus) | MGG_04911 | XP_003712400.1 |
Pan troglodytes (chimpanzee) | CYP3A4 | NP_001116247.1 |
Bos taurus (cattle) | CYP3A4 | NP_001092837.1 |
Rattus norvegicus (Norway rat) | Cyp3a2 | NP_695224.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012294 | XP_001238278.2 |
Caenorhabditis elegans (roundworm) | cyp-25A5 | NP_500322.1 |
ABC transporters in the eyes of dogs and implications in drug therapy.
Haritova AM, Krastev SZ, Santos RR, Schrickx JA, Fink-Gremmels J
Current eye research38(2)271-7(2013 Feb)
Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.
Mealey KL, Jabbes M, Spencer E, Akey JM
Xenobiotica; the fate of foreign compounds in biological systems38(10)1305-12(2008 Oct)
Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.
Shou M, Norcross R, Sandig G, Lu P, Li Y, Lin Y, Mei Q, Rodrigues AD, Rushmore TH
Drug metabolism and disposition: the biological fate of chemicals31(9)1161-9(2003 Sep)
Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37).
Ourlin JC, Baader M, Fraser D, Halpert JR, Meyer UA
Archives of biochemistry and biophysics373(2)375-84(2000 Jan)
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR
Biochimica et biophysica acta1088(2)319-22(1991 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CYP3A12 expression was found in the retina and conjunctiva.
Title: ABC transporters in the eyes of dogs and implications in drug therapy.
In summary, these results represent an important step toward the systematic comparison of human and canine CYP3A enzymes, particularly in relation to oral bioavailability of substrate drugs.
Title: Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.
The following CYP3A12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP3A12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00409 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003340.1 | |
Accession Version | NM_001003340.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Canis lupus familiaris(dog) | |
Product | cytochrome P450 3A12 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X54915.1. On Jan 12, 2005 this sequence version replaced XM_537939.1. ##Evidence-Data-START## Transcript exon combination :: X54915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547738, SAMEA4547739 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACTTGA TCCCAAGCTT TTCCACAGAA ACCTGGCTTC TTCTGGCTAT CAGCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003340.1 |
CDS | 78..1589 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003340.1 |
1 | ATGGACTTGA TCCCAAGCTT TTCCACAGAA ACCTGGCTTC TTCTGGCTAT CAGCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
ABC transporters in the eyes of dogs and implications in drug therapy. |
Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine. |
Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. |
Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). |
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. |