Gene Symbol | HSP90B1 |
Entrez Gene ID | 404019 |
Full Name | heat shock protein 90 beta family member 1 |
Synonyms | GRP94,TRA1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » HSP90B1 cDNA ORF clone
Gene Symbol | HSP90B1 |
Entrez Gene ID | 404019 |
Full Name | heat shock protein 90 beta family member 1 |
Synonyms | GRP94,TRA1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001003327.2 | NP_001003327.1 | endoplasmin precursor |
HSP90B1 | XP_001095189.1 | |
Mus musculus (house mouse) | Hsp90b1 | NP_035761.1 |
Rattus norvegicus (Norway rat) | Hsp90b1 | NP_001012197.2 |
Homo sapiens (human) | HSP90B1 | NP_003290.1 |
Canis lupus familiaris (dog) | HSP90B1 | NP_001003327.1 |
Bos taurus (cattle) | HSP90B1 | NP_777125.1 |
Oryza sativa (rice) | Os06g0716700 | NP_001058590.1 |
Gallus gallus (chicken) | HSP90B1 | NP_989620.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001424 | XP_321706.5 |
Caenorhabditis elegans (roundworm) | CELE_T05E11.3 | NP_001255536.1 |
Danio rerio (zebrafish) | hsp90b1 | NP_937853.1 |
Drosophila melanogaster (fruit fly) | Gp93 | NP_651601.1 |
Arabidopsis thaliana (thale cress) | SHD | NP_974606.1 |
Xenopus tropicalis (tropical clawed frog) | hsp90b1 | NP_001039228.1 |
Pan troglodytes (chimpanzee) | HSP90B1 | NP_001233416.1 |
Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy.
Jahn M, Tych K, Girstmair H, Steinma?l M, Hugel T, Buchner J, Rief M
Structure (London, England : 1993)26(1)96-105.e4(2018 Jan)
Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Huck JD, Que NL, Hong F, Li Z, Gewirth DT
Cell reports20(12)2800-2809(2017 Sep)
The overexpression of Hsp90B1 is associated with tumorigenesis of canine mammary glands.
Sunil Kumar BV, Bhardwaj R, Mahajan K, Kashyap N, Kumar A, Verma R
Molecular and cellular biochemistry(2017 Aug)
Heat shock protein 90 is associated with hyperplasia and neoplastic transformation of canine prostatic epithelial cells.
Palmieri C, Mancini M, Benazzi C, Della Salda L
Journal of comparative pathology150(4)393-8(2014 May)
Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs.
Kanamaru C, Yamada Y, Hayashi S, Matsushita T, Suda A, Nagayasu M, Kimura K, Chiba S
The Journal of toxicological sciences39(1)59-69(2014 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increased HSP90 expression in canine PCs suggests the involvement of this molecule in carcinogenesis and tumour progression, supporting HSP90 as a potential target for therapeutic intervention.
Title: Heat shock protein 90 is associated with hyperplasia and neoplastic transformation of canine prostatic epithelial cells.
is a constitutively expressed molecular chaperone and plays an important role in the folding of client proteins with key regulatory roles in growth, survival, differentiation and metastasis.
Title: Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs.
The ATPase activity of GRP94 is essential for chaperone activity in vivo and the essential protein-binding domain of GRP94 is distinct from the N-terminal domain.
Title: An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.
expression of TLR2, but not TLR4, on synovial fluid macrophages strongly correlated with the level of gp96 in the synovial fluid
Title: Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Data report the 2.4 A crystal structure of GRP94 in complex with AMPPNP and ADP, and provide a structural explanation for GRP94's observed rate of ATP hydrolysis.
Title: Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones.
The following HSP90B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSP90B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe191406 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003327.2 | |
Accession Version | NM_001003327.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2415bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Canis lupus familiaris(dog) | |
Product | endoplasmin precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN355411.1, DN342500.1, DN350233.1, DN367458.1, DN872944.1, CO697089.1, DN339507.1, DN410215.1, CO708092.1, CO716128.1 and CO594038.1. On Sep 1, 2015 this sequence version replaced NM_001003327.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U01153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCAGTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003327.1 |
CDS | 96..2510 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003327.2 |
1 | ATGAGGGCCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTCAGTCCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy. |
Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site. |
The overexpression of Hsp90B1 is associated with tumorigenesis of canine mammary glands. |
Heat shock protein 90 is associated with hyperplasia and neoplastic transformation of canine prostatic epithelial cells. |
Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs. |