Gene Symbol | RHOA |
Entrez Gene ID | 403954 |
Full Name | ras homolog family member A |
Synonyms | RHO1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » RHOA cDNA ORF clone
Gene Symbol | RHOA |
Entrez Gene ID | 403954 |
Full Name | ras homolog family member A |
Synonyms | RHO1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_005632310.3 | XP_005632367.1 | transforming protein RhoA isoform X1 |
XM_005632310.2 | XP_005632367.1 | transforming protein RhoA isoform X1 |
NM_001003273.3 | NP_001003273.2 | transforming protein RhoA precursor |
Homo sapiens (human) | RHOA | NP_001655.1 |
Canis lupus familiaris (dog) | RHOA | NP_001003273.2 |
Mus musculus (house mouse) | Rhoa | NP_058082.2 |
Gallus gallus (chicken) | RHOA | NP_990035.1 |
Eremothecium gossypii | AGOS_ABR183W | NP_983131.1 |
Schizosaccharomyces pombe (fission yeast) | rho1 | NP_594490.1 |
Neurospora crassa | NCU01484 | XP_956761.2 |
Pan troglodytes (chimpanzee) | RHOA | XP_003950161.1 |
Bos taurus (cattle) | RHOA | NP_788818.1 |
Rattus norvegicus (Norway rat) | Rhoa | NP_476473.1 |
Danio rerio (zebrafish) | rhoab | NP_997914.2 |
Kluyveromyces lactis | KLLA0B10626g | XP_452002.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_07176 | XP_003715379.1 |
Schizosaccharomyces pombe (fission yeast) | rho5 | NP_593631.1 |
Saccharomyces cerevisiae (baker's yeast) | RHO1 | NP_015491.1 |
Xenopus tropicalis (tropical clawed frog) | rhoa.2 | NP_001016648.1 |
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Raya-Sandino A, Castillo-Kauil A, Dom?nguez-Calder?n A, Alarc?n L, Flores-Benitez D, Cuellar-Perez F, L?pez-Bayghen B, Ch?vez-Mungu?a B, V?zquez-Prado J, Gonz?lez-Mariscal L
Biochimica et biophysica acta1864(10)1714-1733(2017 10)
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.
Reffay M, Parrini MC, Cochet-Escartin O, Ladoux B, Buguin A, Coscoy S, Amblard F, Camonis J, Silberzan P
Nature cell biology16(3)217-23(2014 Mar)
The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites.
Zhang W, Huang Y, Gunst SJ
The Journal of biological chemistry287(41)33996-4008(2012 Oct)
The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.
Kakiashvili E, Dan Q, Vandermeer M, Zhang Y, Waheed F, Pham M, Sz?szi K
The Journal of biological chemistry286(11)9268-79(2011 Mar)
The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization.
Zhang W, Du L, Gunst SJ
American journal of physiology. Cell physiology299(2)C298-306(2010 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation.
Title: Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
RhoA controls the development cell migration fingers through mechanical cues.
Title: Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.
the RhoA-mediated assembly of adhesome complexes is a fundamental step in the signal transduction process in response to agonist -induced smooth muscle contraction.
Title: The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites.
the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation.
Title: The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.
Activation of the small GTPase RhoA plays a critical role in the regulation of force generation in intact airway smooth muscle tissues activated by muscarinic stimulation.
Title: The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization.
The following RHOA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHOA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00366 | |
Clone ID Related Accession (Same CDS sequence) | XM_005632310.3 , XM_005632310.2 , NM_001003273.3 | |
Accession Version | NM_001003273.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-13 | |
Organism | Canis lupus familiaris(dog) | |
Product | transforming protein RhoA precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN394819.1, CN004448.1 and DR102913.1. On Jun 21, 2011 this sequence version replaced NM_001003273.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DN877451.1, GR899294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003273.2 |
CDS | 248..829 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003273.3 |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe00366 | |
Clone ID Related Accession (Same CDS sequence) | XM_005632310.3 , XM_005632310.2 , NM_001003273.3 | |
Accession Version | XM_005632310.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | transforming protein RhoA isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006602.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005632310.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005632367.1 |
CDS | 391..972 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005632310.3 |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe00366 | |
Clone ID Related Accession (Same CDS sequence) | XM_005632310.3 , XM_005632310.2 , NM_001003273.3 | |
Accession Version | XM_005632310.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | transforming protein RhoA isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726096.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005632310.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005632367.1 |
CDS | 367..948 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005632310.2 |
1 | ATGGCTGCCA TCCGGAAGAA ACTGGTGATT GTTGGTGATG GAGCCTGTGG TAAGACTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. |
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells. |
The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites. |
The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium. |
The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization. |