AR cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	AR
Entrez Gene ID	403588
Full Name	androgen receptor
General protein information	Preferred Names androgen receptor Names androgen receptor androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) dihydrotestosterone receptor nuclear receptor subfamily 3 group C member 4
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003053.1	NP_001003053.1	androgen receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AR	NP_001231056.1
Homo sapiens (human)	AR	NP_000035.2
Canis lupus familiaris (dog)	AR	NP_001003053.1
Rattus norvegicus (Norway rat)	Ar	NP_036634.1
Mus musculus (house mouse)	Ar	NP_038504.1
	AR	NP_001028083.1
Gallus gallus (chicken)	AR	NP_001035179.1
Xenopus tropicalis (tropical clawed frog)	ar	XP_002941888.2

Gene Ontology
Bibliography

Related articles in PubMed

Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines.
Kato Y, Ochiai K, Kawakami S, Nakao N, Azakami D, Bonkobara M, Michishita M, Morimatsu M, Watanabe M, Omi T
BMC veterinary research13(1)170(2017 Jun)

Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
Chuffa LG, Lupi J?nior LA, da Maia Lima AF
Tissue & cell48(1)10-7(2016 Feb)

Variability of CAG tandem repeats in exon 1 of the androgen receptor gene is not related with dog intersexuality.
Nowacka-Woszuk J, Switonski M
Animal reproduction science117(3-4)308-13(2010 Feb)

Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.
Gallardo F, Lloreta J, Garc?a F, Moll X, Bar? T, Gonz?lez LA, Morote J, Reventos J, Mogas T
Journal of andrology30(3)240-7(2009 May-Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the effects of REIC/Dkk-3 and small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) interactions on androgen receptor signaling in the canine androgen-independent prostate cancer cell line CHP-1
Title: Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines.

We concluded that sex steroid receptors and apoptotic proteins are differentially expressed in the follicles of adult dogs with polystic ovaries
Title: Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.

None of the detected polymorphisms, including variability of the CAG tandem repeats, could be related with the intersexual phenotype of the studied dogs.
Title: Variability of CAG tandem repeats in exon 1 of the androgen receptor gene is not related with dog intersexuality.

Androgen receptor staining was observed in most tumors from intact and castrated dogs, but the proportion of positive cells and the staining intensity were much lower than in the prostate of healthy, non-castrated dogs.
Title: Immunostaining of the androgen receptor and sequence analysis of its DNA-binding domain in canine prostate cancer.

AR, ER alpha, and ER beta are differently expressed in canine prostate tissue
Title: Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.

The following AR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00346	NM_001003053.1 Latest version!	Canis lupus familiaris androgen receptor (AR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AR ( NM_001003053.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003053.1 Canis lupus familiaris androgen receptor (AR), mRNA.

Price & Availability↑

CloneID	OCe00346
Clone ID Related Accession (Same CDS sequence)	NM_001003053.1
Accession Version	NM_001003053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2724bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Canis lupus familiaris(dog)
Product	androgen receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF197950.1. ##Evidence-Data-START## CDS exon combination :: AF197950.1 [ECO:0000331] ##Evidence-Data-END##

ATGGAGGTAC AGTTAGGGCT AGGGAGGGTC TACCCCCGGC CGCCGTCCAA GACCTATCGA 
GGAGCTTTCC AGAACCTGTT CCAGAGTGTG CGCGAAGTGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGTGAGCGC AGCACCTCCC GGTGCCCATT TGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGGAGACCAG TCCTCGGCAG CAGCAGCAGC AACAGCAGGG TGACGATGGC 
TCTCCCCAAG CGCAGAGCAG AGGCCCCACA GGCTACCTGG CTCTGGATGA GGAACAGCAG 
CCTTCCCAAC AGCGGTCAGC CTCCAAGGGC CATCCGGAGA GTGCCTGCGT TCCAGAGCCT 
GGAGTGACTT CGGCCACCGG CAAGGGGCTG CAGCAGCAGC AGCCAGCACC ACCGGACGAG 
AATGACTCAG CTGCCCCATC CACATTGTCA CTGCTGGGCC CCACTTTCCC GGGCTTAAGT 
AGCTGTTCCA CCGATCTTAA AGACATCCTG AGCGAGGCTG GAACCATGCA ACTCCTTCAG 
CAGCAGCGGC AGCAGCAGCA GCAGCAGCAG CAACAGCAAC AGCAGCAGCA GCAGCAGCAA 
CAGCAGGAGG TAGTATCAGA AGGTAGCAGC AGCGGGAGAG CAAGGGAGGC CGCCGGTGCT 
TCCACCTCCT CCAAGGACAG TTACCTAGGT GGCAGTTCGA CCATCTCGGA CAGCGCCAAG 
GAGTTGTGTA AGGCAGTGTC GGTGTCCATG GGTTTGGGTG TGGAGGCATT GGAACATCTG 
AGCCCTGGGG AACAGCTTCG GGGGGATTGT ATGTACGCCC CGCTCCTGGG AGGTCCACCC 
GCCGTACGTC CTTGCGCTCC GCTGGCCGAA TGCAAAGGTT CTCTGCTGGA TGACGGCCCG 
GGCAAGGGCA CCGAAGAAAC TGCTGAATAT TCCCCTTTCA AGGCAGGTTA TGCGAAAGGG 
TTGGATGGGG ACAGCCTGGG CTGTTCGAGC AGCAGTGAAG CAGGGGGCTC CGGAACACTT 
GAGATGCCAT CCACCCTGTC TCTTTACAAG TCTGGAGCAC TAGATGAAGC GGCAGCTTAT 
CAAAGTCGAG ACTACTACAA CTTTCCTCTC TCCCTAGGCG GGCCGCCTCC CCATCCACCA 
CCTCCCCATC CTCACACCCG CATCAAGCTG GAAAACCCTC TGGACTATGG CAGCGCCTGG 
GCGGCTGCAG CGGCACAATG CCGCTACGGG GATCTGGCGA GCCTGCACGG AGCGGGTGCA 
GCAGGACCCA GCTCGGGCTC ACCTTCGGCC ACCACCTCCT CTTCCTGGCA CACTCTCTTC 
ACAGCAGAAG AAGGCCAGCT GTATGGGCCC TGCGGCGGGA GTGGAGGCGG CAGTGCAGGC 
GACGGGGGAT CTGTAGCCCC CTATGGCTAC ACTCGGCCAC CTCAGGGATT GGCGGGTCAG 
GAAGGTGACT TCCCTCCACC TGATGTGTGG TATCCGGGCG GTGTGGTGAG CAGAGTGCCC 
TTTCCAAGTC CTAGTTGTGT CAAAAGCGAG ATGGGCTCTT GGATGGAGAG CTACTCCGGA 
CCCTATGGGG ACATGCGTTT GGAGACTGCC AGGGACCATG TTCTACCCAT TGACTATTAC 
TTTCCACCTC AGAAGACCTG TCTGATCTGC GGTGATGAAG CTTCTGGCTG TCACTATGGA 
GCTCTCACTT GTGGAAGCTG CAAAGTCTTC TTTAAAAGAG CCGCTGAAGG GAAACAGAAG 
TACCTGTGTG CCAGCAGAAA TGATTGTACC ATCGATAAAT TCCGAAGGAA AAATTGTCCA 
TCTTGTCGCC TCCGGAAATG CTATGAAGCA GGGATGACTC TGGGAGCCCG GAAGCTAAAG 
AAACTGGGGA ATCTGAAACT GCAAGAGGAA GGAGAGGCTT CCAATGTCAC CAGCCCCACT 
GAGGAGCCAA CCCAGAAGCT GACGGTGTCA CACATTGAAG GCTATGAGTG TCAGCCCATC 
TTTCTGAATG TCCTTGAAGC CATCGAGCCA GGCGTGGTGT GTGCTGGACA TGACAACAAC 
CAGCCCGACT CCTTTGCAGC CTTGCTCTCT AGCCTTAATG AATTGGGTGA AAGGCAGCTT 
GTACATGTGG TCAAGTGGGC CAAGGCCTTG CCGGGCTTCC GCAACCTGCA CGTGGATGAC 
CAGATGGCAG TCATTCAGTA CTCCTGGATG GGGCTCATGG TGTTTGCCAT GGGCTGGCGA 
TCCTTCACCA ATGTCAACTC CAGGATGCTC TACTTCGCCC CTGACCTGGT TTTCAATGAG 
TACCGCATGC ACAAGTCCCG GATGTACAGC CAGTGTGTCC GAATGAGGCA CCTCTCTCAA 
GAATTTGGAT GGCTCCAAAT CACCCCGCAG GAATTTTTGT GCATGAAGGC GCTGCTGCTA 
TTCAGCATTA TTCCAGTGGA TGGGCTGAAA AATCAAAAAT TCTTTGATGA ACTTCGAATG 
AACTACATCA AGGAACTTGA TCGTATCATT GCTTGCAAGA GAAAAAATCC CACATCCTGC 
TCAAGGCGCT TCTACCAGCT CACCAAGCTC CTGGACTCTG TGCAACCTAT TGCTCGAGAG 
CTGCATCAGT TCACTTTTGA CCTGCTAATC AAGTCCCACA TGGTGAGCGT GGACTTTCCA 
GAAATGATGG CAGAAATCAT CTCCGTGCAA GTGCCCAAGA TTCTTTCTGG GAAAGTCAAG 
CCCATCTATT TCCACACGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003053.1
CDS	1..2724
Translation	MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAVSAAPPGAHLQQQQQQQQQQETSPRQQQQQQQGDDGSPQAQSRGPTGYLALDEEQQPSQQRSASKGHPESACVPEPGVTSATGKGLQQQQPAPPDENDSAAPSTLSLLGPTFPGLSSCSTDLKDILSEAGTMQLLQQQRQQQQQQQQQQQQQQQQQQQEVVSEGSSSGRAREAAGASTSSKDSYLGGSSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGGPPAVRPCAPLAECKGSLLDDGPGKGTEETAEYSPFKAGYAKGLDGDSLGCSSSSEAGGSGTLEMPSTLSLYKSGALDEAAAYQSRDYYNFPLSLGGPPPHPPPPHPHTRIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPSSGSPSATTSSSWHTLFTAEEGQLYGPCGGSGGGSAGDGGSVAPYGYTRPPQGLAGQEGDFPPPDVWYPGGVVSRVPFPSPSCVKSEMGSWMESYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASNVTSPTEEPTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Target ORF information:

RefSeq Version	NM_001003053.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris androgen receptor (AR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003053.1

ORF Insert Sequence:

ATGGAGGTAC AGTTAGGGCT AGGGAGGGTC TACCCCCGGC CGCCGTCCAA GACCTATCGA 
GGAGCTTTCC AGAACCTGTT CCAGAGTGTG CGCGAAGTGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGTGAGCGC AGCACCTCCC GGTGCCCATT TGCAGCAGCA GCAGCAGCAG 
CAGCAGCAGC AGGAGACCAG TCCTCGGCAG CAGCAGCAGC AACAGCAGGG TGACGATGGC 
TCTCCCCAAG CGCAGAGCAG AGGCCCCACA GGCTACCTGG CTCTGGATGA GGAACAGCAG 
CCTTCCCAAC AGCGGTCAGC CTCCAAGGGC CATCCGGAGA GTGCCTGCGT TCCAGAGCCT 
GGAGTGACTT CGGCCACCGG CAAGGGGCTG CAGCAGCAGC AGCCAGCACC ACCGGACGAG 
AATGACTCAG CTGCCCCATC CACATTGTCA CTGCTGGGCC CCACTTTCCC GGGCTTAAGT 
AGCTGTTCCA CCGATCTTAA AGACATCCTG AGCGAGGCTG GAACCATGCA ACTCCTTCAG 
CAGCAGCGGC AGCAGCAGCA GCAGCAGCAG CAACAGCAAC AGCAGCAGCA GCAGCAGCAA 
CAGCAGGAGG TAGTATCAGA AGGTAGCAGC AGCGGGAGAG CAAGGGAGGC CGCCGGTGCT 
TCCACCTCCT CCAAGGACAG TTACCTAGGT GGCAGTTCGA CCATCTCGGA CAGCGCCAAG 
GAGTTGTGTA AGGCAGTGTC GGTGTCCATG GGTTTGGGTG TGGAGGCATT GGAACATCTG 
AGCCCTGGGG AACAGCTTCG GGGGGATTGT ATGTACGCCC CGCTCCTGGG AGGTCCACCC 
GCCGTACGTC CTTGCGCTCC GCTGGCCGAA TGCAAAGGTT CTCTGCTGGA TGACGGCCCG 
GGCAAGGGCA CCGAAGAAAC TGCTGAATAT TCCCCTTTCA AGGCAGGTTA TGCGAAAGGG 
TTGGATGGGG ACAGCCTGGG CTGTTCGAGC AGCAGTGAAG CAGGGGGCTC CGGAACACTT 
GAGATGCCAT CCACCCTGTC TCTTTACAAG TCTGGAGCAC TAGATGAAGC GGCAGCTTAT 
CAAAGTCGAG ACTACTACAA CTTTCCTCTC TCCCTAGGCG GGCCGCCTCC CCATCCACCA 
CCTCCCCATC CTCACACCCG CATCAAGCTG GAAAACCCTC TGGACTATGG CAGCGCCTGG 
GCGGCTGCAG CGGCACAATG CCGCTACGGG GATCTGGCGA GCCTGCACGG AGCGGGTGCA 
GCAGGACCCA GCTCGGGCTC ACCTTCGGCC ACCACCTCCT CTTCCTGGCA CACTCTCTTC 
ACAGCAGAAG AAGGCCAGCT GTATGGGCCC TGCGGCGGGA GTGGAGGCGG CAGTGCAGGC 
GACGGGGGAT CTGTAGCCCC CTATGGCTAC ACTCGGCCAC CTCAGGGATT GGCGGGTCAG 
GAAGGTGACT TCCCTCCACC TGATGTGTGG TATCCGGGCG GTGTGGTGAG CAGAGTGCCC 
TTTCCAAGTC CTAGTTGTGT CAAAAGCGAG ATGGGCTCTT GGATGGAGAG CTACTCCGGA 
CCCTATGGGG ACATGCGTTT GGAGACTGCC AGGGACCATG TTCTACCCAT TGACTATTAC 
TTTCCACCTC AGAAGACCTG TCTGATCTGC GGTGATGAAG CTTCTGGCTG TCACTATGGA 
GCTCTCACTT GTGGAAGCTG CAAAGTCTTC TTTAAAAGAG CCGCTGAAGG GAAACAGAAG 
TACCTGTGTG CCAGCAGAAA TGATTGTACC ATCGATAAAT TCCGAAGGAA AAATTGTCCA 
TCTTGTCGCC TCCGGAAATG CTATGAAGCA GGGATGACTC TGGGAGCCCG GAAGCTAAAG 
AAACTGGGGA ATCTGAAACT GCAAGAGGAA GGAGAGGCTT CCAATGTCAC CAGCCCCACT 
GAGGAGCCAA CCCAGAAGCT GACGGTGTCA CACATTGAAG GCTATGAGTG TCAGCCCATC 
TTTCTGAATG TCCTTGAAGC CATCGAGCCA GGCGTGGTGT GTGCTGGACA TGACAACAAC 
CAGCCCGACT CCTTTGCAGC CTTGCTCTCT AGCCTTAATG AATTGGGTGA AAGGCAGCTT 
GTACATGTGG TCAAGTGGGC CAAGGCCTTG CCGGGCTTCC GCAACCTGCA CGTGGATGAC 
CAGATGGCAG TCATTCAGTA CTCCTGGATG GGGCTCATGG TGTTTGCCAT GGGCTGGCGA 
TCCTTCACCA ATGTCAACTC CAGGATGCTC TACTTCGCCC CTGACCTGGT TTTCAATGAG 
TACCGCATGC ACAAGTCCCG GATGTACAGC CAGTGTGTCC GAATGAGGCA CCTCTCTCAA 
GAATTTGGAT GGCTCCAAAT CACCCCGCAG GAATTTTTGT GCATGAAGGC GCTGCTGCTA 
TTCAGCATTA TTCCAGTGGA TGGGCTGAAA AATCAAAAAT TCTTTGATGA ACTTCGAATG 
AACTACATCA AGGAACTTGA TCGTATCATT GCTTGCAAGA GAAAAAATCC CACATCCTGC 
TCAAGGCGCT TCTACCAGCT CACCAAGCTC CTGGACTCTG TGCAACCTAT TGCTCGAGAG 
CTGCATCAGT TCACTTTTGA CCTGCTAATC AAGTCCCACA TGGTGAGCGT GGACTTTCCA 
GAAATGATGG CAGAAATCAT CTCCGTGCAA GTGCCCAAGA TTCTTTCTGG GAAAGTCAAG 
CCCATCTATT TCCACACGCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines.
BMC veterinary research13(1)170(2017 Jun)
Kato Y,Ochiai K,Kawakami S,Nakao N,Azakami D,Bonkobara M,Michishita M,Morimatsu M,Watanabe M,Omi T

Sex steroid receptors and apoptosis-related proteins are differentially expressed in polycystic ovaries of adult dogs.
Tissue & cell48(1)10-7(2016 Feb)
Chuffa LG,Lupi J?nior LA,da Maia Lima AF

Variability of CAG tandem repeats in exon 1 of the androgen receptor gene is not related with dog intersexuality.
Animal reproduction science117(3-4)308-13(2010 Feb)
Nowacka-Woszuk J,Switonski M

Immunolocalization of androgen receptors, estrogen alpha receptors, and estrogen beta receptors in experimentally induced canine prostatic hyperplasia.
Journal of andrology30(3)240-7(2009 May-Jun)
Gallardo F,Lloreta J,Garc?a F,Moll X,Bar? T,Gonz?lez LA,Morote J,Reventos J,Mogas T

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AR cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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