TPO cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	TPO
Entrez Gene ID	403521
Full Name	thyroid peroxidase
General protein information	Preferred Names thyroid peroxidase Names thyroid peroxidase
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003009.2	NP_001003009.2	thyroid peroxidase precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TPO	NP_000538.3
Rattus norvegicus (Norway rat)	Tpo	NP_062226.2
Xenopus tropicalis (tropical clawed frog)	tpo	XP_002936348.2
Gallus gallus (chicken)	TPO	XP_001235673.2
Pan troglodytes (chimpanzee)	TPO	XP_003308907.1
Canis lupus familiaris (dog)	TPO	NP_001003009.2
Mus musculus (house mouse)	Tpo	NP_033443.1
Danio rerio (zebrafish)	LOC100331172	XP_003201429.2
	TPO	XP_001117795.1
Bos taurus (cattle)	TPO	XP_002683990.1

Gene Ontology
Bibliography

Related articles in PubMed

A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure.
Fyfe JC, Lynch M, Olsen J, Lou?r E
Mammalian genome : official journal of the International Mammalian Genome Society24(3-4)127-33(2013 Apr)

Congenital hypothyroidism with goiter in toy fox terriers.
Fyfe JC, Kampschmidt K, Dang V, Poteet BA, He Q, Lowrie C, Graham PA, Fetro VM
Journal of veterinary internal medicine17(1)50-7(2003 Jan-Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The disease-causing mutation is within an additional coding sequence in the 5\' TPO cDNA, which demonstrates that the gene structure is canid-specific.
Title: A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure.

The following TPO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00268	NM_001003009.2 Latest version!	Canis lupus familiaris thyroid peroxidase (TPO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TPO ( NM_001003009.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003009.2 Canis lupus familiaris thyroid peroxidase (TPO), mRNA.

Price & Availability↑

CloneID	OCe00268
Clone ID Related Accession (Same CDS sequence)	NM_001003009.2
Accession Version	NM_001003009.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2838bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Canis lupus familiaris(dog)
Product	thyroid peroxidase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY094504.2. On Oct 8, 2011 this sequence version replaced NM_001003009.1. ##Evidence-Data-START## Transcript exon combination :: AY094504.2 [ECO:0000332] ##Evidence-Data-END##

ATGGTCGGCC TGGTCCCCGC CGGCTCCGCC TGGGGGGGGA GAGCACTCGC CGTCCTGGGC 
GTCACGCTGC TGGTGGCCCT CGCGCGCGGC CTCCTCCCCT TCTTCCTCGG AGGCCGGGAC 
CTCCTGTGGG GACAGAGCGG AGAGGCCAGT GTCCTTGGCG TCGTGGAGGA GAGCCGGCGC 
GTGGTGGACG GCGCCATCCA GCACACCGTG AGGAGAGACC TCAGCAAAAG GGGGCTCCCT 
TCCCCGTCGC AGCTTCTGTC TTTTTCCAAA CTCCCCGAGC CGACCAGCCG AGCCGTCTCC 
CGAGCGGCGG AGATCATGGA AGCCTCCGTG CAGGCCGTGA GGACACGGGT CTATGGGAAG 
CTGGGGCGAT CTTGGCCTCT CACCGACACG CTGCCCGAAG CCGTGCTGGA CACGATTGCC 
AACGCGTCCG GGTGTCGGCC CCACATGCTG CCCCCCAGGT GCCCGGACAC CTGCCTGGCC 
CGCAAGTACC GGCTCATCAC GGGCGCCTGC AACAACAGAG ACCACCCCAG GTGGGGAGCC 
TCCAACACAG CGCTGGCGAG GTGGCTGCCG CCCGCCTACG AAGACGGCAT CAGTGAGCCC 
AGAGGGTGGA ACCCCCACGT CCTGTACAGC GGCTTCCCGC TGCCCCCGGT GCGGGAAGTG 
ACCAGACAGG TTATCCGGGT CCCCAACGAG GCCATCACAG AGGACGACCA GTATTCGGAT 
CTCCTGACGG TGTGGGGCCA GTACATCGAC CACGACGTCG CGTTCACACC GCAGAGTGCC 
AGCGGAGCTG CGTTCGGGGC GGGAGCTGAC TGCCAGCTGA CGTGTGAGAA CCGGAGCCCG 
TGTTTTCCCA TCCAGCTGCC CCCCGATGCC TCGGGGCCCG CCTGCTTGCC CTTCTCCCGC 
TCCTCTGCCG CCTGCGGCAC CGGGATCCAA GGCGCCTTCT TCGGCAACCT GAGCTCGGCC 
AACCCGCGGC AGCAGATGAA CGGGCTGACG TCCTTCCTGG ACGCGTCCAC GGTGTACGGC 
AGCTCCCCGG CCTTGGAGAA GCAGCTGCGC AACTGGACCA GTGCCGAGGG GCTGCTCCGC 
GTCAACACGC GCCACTGGGA CGCCGGCCGC GCCCACCTGC CCTTCATGCG GCCGCCTGCG 
CCCTTGGCCT GCGTGCCCGA GCCCGGCACC CGCGGGACGG CCGGAGCGCC CTGCTTCCTG 
GCGGGGGACA GCCGTGCCAG CGAGGTCCCC ACTCTGGCGG CCCTTCACAC GCTGTGGCTG 
CGCGAGCACA ACCGCCTGGC CTCGGCGCTC AAGGCTCTCA ACGCTCACTG GAGCGCGGAT 
ACCGCCTACC AGGAGGCGCG CAAGGTGGTG GGCGCCCTGC ACCAGATCAT CACCTTGCGG 
GACTACGTCC CCAAAGTCCT GGGCCCCGAG GCCTTCCAGC AGCACGTGGG CCCCTACGAG 
GGTTACGACC CCACCATGGA CCCCACCGTG TCCAACGTGT TTTCCACGGC CGCCTTCCGC 
TTCGGCCACG CCACGGTGCA CCCGCTGGTG AGGCGGCTGG ACGCCCGCTT CCAGGAGCAC 
CCCGGCCTCC CCCCGCTGCG GCTGCAGGAC GCCTTCTTCA GCCCCTGGAG GCTCCTCAAG 
GAAGGTGGTC TGGACCCCCT GCTGAGGGGC CTTCTCGCGA GCCCCGCCAA GTTGCCGGTG 
CAGGAGCAGC TGATGAATGA GGAGCTGACC GAGAGGCTGT TCGTGCTGGG CAGCTCAGGC 
AGCCTGGACC TGGCGTCCAT AAACCTGCAG CGGGGCCGGG ACCACGGCCT GCCAGGTTAC 
AACGCGTGGA GGGAGTTCTG CGGCCTGGGC CGGCTGCACA CGCGGGCCGA GCTGCGCTCC 
GCCGTCGCCA ACGCCACCCT CGCCGGCCGG ATCATGGACC TGTACGGGCA CCCCGACAAC 
ATCGACGTCT GGCTGGGCGG CCTGGCCGAG CCCCTCCTCC CCCGGGCGCG CACGGGCCCG 
CTGTTTGCGT GCCTCATCGG GAGGCAGATG AAGGCTCTGA GGGACGGAGA CCGGTTCTGG 
TGGGAGAGCA GCGGGGTGTT CACCGACGAG CAGCGGCGCG AGCTGGCGAG GCACTCCCTG 
TCCCGGGTCA TCTGTGACAA CACGGGCCTC CCCAGCGTGC CCGCGGACGC CTTCCAGGTC 
AGCAGATTCC CACAGGACTT CGAGCCGTGC GAGAACATTC CGGGTCTGAA CCTGGACGTG 
TGGAGGGAGG CCCTTCCGCA AGGCGACGCC TGCGGCCTCC CCGACAGCCT GGACAATGGG 
GACGTCGTGC TCTGCGGCGA GGCCGGGCGG CGCGTGCTCG TCTTCTCCTG CCGCCACGGG 
TTCAAGCTGC AGGGCCCCGA GCAGGTGGCC TGCTCCCCCC GGGGCGGGGC TGTCCGGGCC 
CCCGTGTGCA GAGATATCAA TGAGTGTGAA GACGCGAGCC ACCCCCCCTG TCACGGGTCG 
GCCCGGTGCA GGAACACCAA GGGTGGTTTC AGGTGTGAGT GCACAGACCC TGCGGTGCTC 
GGGGAGGACG GAACGACGTG TGTAGACTCC GGGAGGCTCC CGAAGGCGTC CTTGGTCTCC 
ATCGCGTTGG GCATCGTGCT GGTCGTTGGC CTGGCGGGTC TCACCTGGAC GCTGGTTTGC 
AGGTGGGCAC ATGCGGGCCG CAAAGCCTCA CTGAGCATCG CGGAGTTGGG CGGAAGAGGA 
GCCCCCCCGC CGGGCCGTGG AGCGGGCCAG GACGGCGCCT CTGGCAGCCT GGTGCCCCCC 
CTCGGGCCGC AGGGCAGGAC CCGGGCCGTG GACCCCACAT CCAGTAGGAG CCACGTGGCG 
CAGGGAAGCC CGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003009.2
CDS	123..2960
Translation	MVGLVPAGSAWGGRALAVLGVTLLVALARGLLPFFLGGRDLLWGQSGEASVLGVVEESRRVVDGAIQHTVRRDLSKRGLPSPSQLLSFSKLPEPTSRAVSRAAEIMEASVQAVRTRVYGKLGRSWPLTDTLPEAVLDTIANASGCRPHMLPPRCPDTCLARKYRLITGACNNRDHPRWGASNTALARWLPPAYEDGISEPRGWNPHVLYSGFPLPPVREVTRQVIRVPNEAITEDDQYSDLLTVWGQYIDHDVAFTPQSASGAAFGAGADCQLTCENRSPCFPIQLPPDASGPACLPFSRSSAACGTGIQGAFFGNLSSANPRQQMNGLTSFLDASTVYGSSPALEKQLRNWTSAEGLLRVNTRHWDAGRAHLPFMRPPAPLACVPEPGTRGTAGAPCFLAGDSRASEVPTLAALHTLWLREHNRLASALKALNAHWSADTAYQEARKVVGALHQIITLRDYVPKVLGPEAFQQHVGPYEGYDPTMDPTVSNVFSTAAFRFGHATVHPLVRRLDARFQEHPGLPPLRLQDAFFSPWRLLKEGGLDPLLRGLLASPAKLPVQEQLMNEELTERLFVLGSSGSLDLASINLQRGRDHGLPGYNAWREFCGLGRLHTRAELRSAVANATLAGRIMDLYGHPDNIDVWLGGLAEPLLPRARTGPLFACLIGRQMKALRDGDRFWWESSGVFTDEQRRELARHSLSRVICDNTGLPSVPADAFQVSRFPQDFEPCENIPGLNLDVWREALPQGDACGLPDSLDNGDVVLCGEAGRRVLVFSCRHGFKLQGPEQVACSPRGGAVRAPVCRDINECEDASHPPCHGSARCRNTKGGFRCECTDPAVLGEDGTTCVDSGRLPKASLVSIALGIVLVVGLAGLTWTLVCRWAHAGRKASLSIAELGGRGAPPPGRGAGQDGASGSLVPPLGPQGRTRAVDPTSSRSHVAQGSPA

Target ORF information:

RefSeq Version	NM_001003009.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris thyroid peroxidase (TPO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003009.2

ORF Insert Sequence:

ATGGTCGGCC TGGTCCCCGC CGGCTCCGCC TGGGGGGGGA GAGCACTCGC CGTCCTGGGC 
GTCACGCTGC TGGTGGCCCT CGCGCGCGGC CTCCTCCCCT TCTTCCTCGG AGGCCGGGAC 
CTCCTGTGGG GACAGAGCGG AGAGGCCAGT GTCCTTGGCG TCGTGGAGGA GAGCCGGCGC 
GTGGTGGACG GCGCCATCCA GCACACCGTG AGGAGAGACC TCAGCAAAAG GGGGCTCCCT 
TCCCCGTCGC AGCTTCTGTC TTTTTCCAAA CTCCCCGAGC CGACCAGCCG AGCCGTCTCC 
CGAGCGGCGG AGATCATGGA AGCCTCCGTG CAGGCCGTGA GGACACGGGT CTATGGGAAG 
CTGGGGCGAT CTTGGCCTCT CACCGACACG CTGCCCGAAG CCGTGCTGGA CACGATTGCC 
AACGCGTCCG GGTGTCGGCC CCACATGCTG CCCCCCAGGT GCCCGGACAC CTGCCTGGCC 
CGCAAGTACC GGCTCATCAC GGGCGCCTGC AACAACAGAG ACCACCCCAG GTGGGGAGCC 
TCCAACACAG CGCTGGCGAG GTGGCTGCCG CCCGCCTACG AAGACGGCAT CAGTGAGCCC 
AGAGGGTGGA ACCCCCACGT CCTGTACAGC GGCTTCCCGC TGCCCCCGGT GCGGGAAGTG 
ACCAGACAGG TTATCCGGGT CCCCAACGAG GCCATCACAG AGGACGACCA GTATTCGGAT 
CTCCTGACGG TGTGGGGCCA GTACATCGAC CACGACGTCG CGTTCACACC GCAGAGTGCC 
AGCGGAGCTG CGTTCGGGGC GGGAGCTGAC TGCCAGCTGA CGTGTGAGAA CCGGAGCCCG 
TGTTTTCCCA TCCAGCTGCC CCCCGATGCC TCGGGGCCCG CCTGCTTGCC CTTCTCCCGC 
TCCTCTGCCG CCTGCGGCAC CGGGATCCAA GGCGCCTTCT TCGGCAACCT GAGCTCGGCC 
AACCCGCGGC AGCAGATGAA CGGGCTGACG TCCTTCCTGG ACGCGTCCAC GGTGTACGGC 
AGCTCCCCGG CCTTGGAGAA GCAGCTGCGC AACTGGACCA GTGCCGAGGG GCTGCTCCGC 
GTCAACACGC GCCACTGGGA CGCCGGCCGC GCCCACCTGC CCTTCATGCG GCCGCCTGCG 
CCCTTGGCCT GCGTGCCCGA GCCCGGCACC CGCGGGACGG CCGGAGCGCC CTGCTTCCTG 
GCGGGGGACA GCCGTGCCAG CGAGGTCCCC ACTCTGGCGG CCCTTCACAC GCTGTGGCTG 
CGCGAGCACA ACCGCCTGGC CTCGGCGCTC AAGGCTCTCA ACGCTCACTG GAGCGCGGAT 
ACCGCCTACC AGGAGGCGCG CAAGGTGGTG GGCGCCCTGC ACCAGATCAT CACCTTGCGG 
GACTACGTCC CCAAAGTCCT GGGCCCCGAG GCCTTCCAGC AGCACGTGGG CCCCTACGAG 
GGTTACGACC CCACCATGGA CCCCACCGTG TCCAACGTGT TTTCCACGGC CGCCTTCCGC 
TTCGGCCACG CCACGGTGCA CCCGCTGGTG AGGCGGCTGG ACGCCCGCTT CCAGGAGCAC 
CCCGGCCTCC CCCCGCTGCG GCTGCAGGAC GCCTTCTTCA GCCCCTGGAG GCTCCTCAAG 
GAAGGTGGTC TGGACCCCCT GCTGAGGGGC CTTCTCGCGA GCCCCGCCAA GTTGCCGGTG 
CAGGAGCAGC TGATGAATGA GGAGCTGACC GAGAGGCTGT TCGTGCTGGG CAGCTCAGGC 
AGCCTGGACC TGGCGTCCAT AAACCTGCAG CGGGGCCGGG ACCACGGCCT GCCAGGTTAC 
AACGCGTGGA GGGAGTTCTG CGGCCTGGGC CGGCTGCACA CGCGGGCCGA GCTGCGCTCC 
GCCGTCGCCA ACGCCACCCT CGCCGGCCGG ATCATGGACC TGTACGGGCA CCCCGACAAC 
ATCGACGTCT GGCTGGGCGG CCTGGCCGAG CCCCTCCTCC CCCGGGCGCG CACGGGCCCG 
CTGTTTGCGT GCCTCATCGG GAGGCAGATG AAGGCTCTGA GGGACGGAGA CCGGTTCTGG 
TGGGAGAGCA GCGGGGTGTT CACCGACGAG CAGCGGCGCG AGCTGGCGAG GCACTCCCTG 
TCCCGGGTCA TCTGTGACAA CACGGGCCTC CCCAGCGTGC CCGCGGACGC CTTCCAGGTC 
AGCAGATTCC CACAGGACTT CGAGCCGTGC GAGAACATTC CGGGTCTGAA CCTGGACGTG 
TGGAGGGAGG CCCTTCCGCA AGGCGACGCC TGCGGCCTCC CCGACAGCCT GGACAATGGG 
GACGTCGTGC TCTGCGGCGA GGCCGGGCGG CGCGTGCTCG TCTTCTCCTG CCGCCACGGG 
TTCAAGCTGC AGGGCCCCGA GCAGGTGGCC TGCTCCCCCC GGGGCGGGGC TGTCCGGGCC 
CCCGTGTGCA GAGATATCAA TGAGTGTGAA GACGCGAGCC ACCCCCCCTG TCACGGGTCG 
GCCCGGTGCA GGAACACCAA GGGTGGTTTC AGGTGTGAGT GCACAGACCC TGCGGTGCTC 
GGGGAGGACG GAACGACGTG TGTAGACTCC GGGAGGCTCC CGAAGGCGTC CTTGGTCTCC 
ATCGCGTTGG GCATCGTGCT GGTCGTTGGC CTGGCGGGTC TCACCTGGAC GCTGGTTTGC 
AGGTGGGCAC ATGCGGGCCG CAAAGCCTCA CTGAGCATCG CGGAGTTGGG CGGAAGAGGA 
GCCCCCCCGC CGGGCCGTGG AGCGGGCCAG GACGGCGCCT CTGGCAGCCT GGTGCCCCCC 
CTCGGGCCGC AGGGCAGGAC CCGGGCCGTG GACCCCACAT CCAGTAGGAG CCACGTGGCG 
CAGGGAAGCC CGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure.
Mammalian genome : official journal of the International Mammalian Genome Society24(3-4)127-33(2013 Apr)
Fyfe JC,Lynch M,Olsen J,Lou?r E

Congenital hypothyroidism with goiter in toy fox terriers.
Journal of veterinary internal medicine17(1)50-7(2003 Jan-Feb)
Fyfe JC,Kampschmidt K,Dang V,Poteet BA,He Q,Lowrie C,Graham PA,Fetro VM

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TPO cDNA ORF clone, Canis lupus familiaris(dog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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