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Homo sapiens (human)

Browse by Letter Index, Genomic Locus


t(4;14) translocations of FGFR3 Constitutive Signaling by Aberrant PI3K in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer TGFBR1 KD Mutants in Cancer
truncated APC mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN Biosynthesis of A2E, implicated in retinal degradation
Defective CUBN causes hereditary megaloblastic anemia 1 Defective TCN2 causes hereditary megaloblastic anemia
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Diseases associated with glycosaminoglycan metabolism
Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2
Infectious disease Minus-strand DNA synthesis
Integration of viral DNA into host genomic DNA RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
p53-Dependent G1/S DNA damage checkpoint Transcriptional activation of cell cycle inhibitor p21
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic Spindle Checkpoint
G1 Phase Cyclin D associated events in G1
Cyclin E associated events during G1/S transition G1/S-Specific Transcription
Inhibition of replication initiation of damaged DNA by RB1/E2F1 DNA replication initiation
CDK-mediated phosphorylation and removal of Cdc6 DNA strand elongation
Establishment of Sister Chromatid Cohesion Cyclin A/B1 associated events during G2/M transition
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Centrosome maturation
M Phase Golgi Cisternae Pericentriolar Stack Reorganization
Condensation of Prometaphase Chromosomes Mitotic Anaphase
M/G1 Transition CDC6 association with the ORC:origin complex
Regulation of mitotic cell cycle Cargo concentration in the ER
Synthesis of wybutosine at G37 of tRNA(Phe) TNFR1-induced NFkappaB signaling pathway
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
HIV Transcription Elongation Abortive elongation of HIV-1 transcript in the absence of Tat
HIV elongation arrest and recovery Formation of HIV elongation complex in the absence of HIV Tat
Pausing and recovery of HIV elongation Tat-mediated HIV elongation arrest and recovery
Synthesis And Processing Of GAG, GAGPOL Polyproteins Host Interactions of HIV factors
Interactions of Vpr with host cellular proteins Vpr-mediated nuclear import of PICs
Nef and signal transduction Virus Assembly and Release
NS1 Mediated Effects on Host Pathways Neurotoxicity of clostridium toxins
Toxicity of tetanus toxin (TeNT) Toxicity of botulinum toxin type C (BoNT/C)
Uptake and function of diphtheria toxin IRAK4 deficiency (TLR2/4)
MyD88 deficiency (TLR5) Amyloid fiber formation
CD28 dependent PI3K/Akt signaling Signaling by the B Cell Receptor (BCR)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Downstream signaling events of B Cell Receptor (BCR)
AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network
Class I MHC mediated antigen processing & presentation Antigen processing: Ubiquitination & Proteasome degradation
ER-Phagosome pathway Innate Immune System
IRAK2 mediated activation of TAK1 complex Toll Like Receptor 3 (TLR3) Cascade
TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 5 (TLR5) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade Initial triggering of complement
Creation of C4 and C2 activators The NLRP3 inflammasome
Advanced glycosylation endproduct receptor signaling Negative regulators of RIG-I/MDA5 signaling
Beta defensins IRF3-mediated induction of type I IFN
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production RAF activation
Negative regulation of MAPK pathway PKA-mediated phosphorylation of CREB
FCERI mediated MAPK activation Regulation of IFNA signaling
Interferon gamma signaling Interleukin receptor SHC signaling
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