DMRT1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	DMRT1
Entrez Gene ID	769693
Full Name	doublesex and mab-3 related transcription factor 1
General protein information	Preferred Names doublesex and mab-3 related transcription factor 1 Names doublesex- and mab-3-related transcription factor 1
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001101831.1	NP_001095301.1	doublesex- and mab-3-related transcription factor 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

DMRT1 is required for M?llerian duct formation in the chicken embryo.
Ayers KL, Cutting AD, Roeszler KN, Sinclair AH, Smith CA
Developmental biology400(2)224-36(2015 Apr)

Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads.
Lambeth LS, Raymond CS, Roeszler KN, Kuroiwa A, Nakata T, Zarkower D, Smith CA
Developmental biology389(2)160-72(2014 May)

Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts.
Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y, Yokoyama T, Kitagawa H, Hoshi N
Poultry science93(4)953-8(2014 Apr)

Temporospatial expression of Dmrt1 in chicken urogenital system (Gallus gallus) using whole mount in situ hybridization.
Yang Y, Gong P, Feng YP, Li SJ, Peng XL, Ran ZP, Qian YG, Gong YZ
Acta biologica Hungarica64(2)161-8(2013 Jun)

The avian Z-linked gene DMRT1 is required for male sex determination in the chicken.
Smith CA, Roeszler KN, Ohnesorg T, Cummins DM, Farlie PG, Doran TJ, Sinclair AH
Nature461(7261)267-71(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that DMRT1 is expressed in the paired Mullerian ducts in the chicken embryo, where it is required for duct formation.
Title: DMRT1 is required for M?llerian duct formation in the chicken embryo.

DMRT1 is an essential sex-linked regulator of gonadal differentiation in avians.
Title: Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads.

Gonadal somatic cells in the male indifferent gonads showed stronger expressions of DMRT1 compared with those in the female indifferent gonads well before the presumptive period of sex determination.
Title: Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts.

The expression of Dmrt1 in male (ZZ) gonads was not twice as much as in female (ZW) gonads, suggesting the existence of other regulatory mechanisms in addition to Z chromosome dosage effect.
Title: Temporospatial expression of Dmrt1 in chicken urogenital system (Gallus gallus) using whole mount in situ hybridization.

results indicate that DMRT1 is required for testis determination in the chicken; data support the Z dosage hypothesis for avian sex determination
Title: The avian Z-linked gene DMRT1 is required for male sex determination in the chicken.

The following DMRT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DMRT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00370	NM_001101831.1 Latest version!	Gallus gallus doublesex and mab-3 related transcription factor 1 (DMRT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DMRT1 ( NM_001101831.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001095301.1 Gallus gallus doublesex and mab-3 related transcription factor 1 (DMRT1), mRNA.

Price & Availability↑

CloneID	OGa00370
Clone ID Related Accession (Same CDS sequence)	NM_001101831.1
Accession Version	NM_001101831.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Gallus gallus(chicken)
Product	doublesex- and mab-3-related transcription factor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ164800.1. On Aug 21, 2007 this sequence version replaced XM_001232982.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ164800.1 [ECO:0000332] ##Evidence-Data-END##

ATGTGGCGGG ACTGCCAGTG CAAGAAGTGC AGCCTGATCG CCGAGCGGCA GCGGGTGATG 
GCCGCGCAGG TTGCACTGAG GAGGCAGCAA GCCCAGGAAG AGGAGCTGGG GATCAGCCAC 
CCTGTACCCC TGCCCAGTGC CCCTGAGCCA GTTGTCAAGA AGAGCAGCAG CAGCAGCTCC 
TGTCTCCTGC GGGACAGCAG CAGCCCTGCT CACTCCACGA GCACGGTGGC AGCAGCAGCA 
GCGAGCGCAC CACCAGGCCA GTGCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095301.1
CDS	5..274
Translation	MWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPVPLPSAPEPVVKKSSSSSSCLLRDSSSPAHSTSTVAAAAASAPPGQCQ

Target ORF information:

RefSeq Version	NM_001101831.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus doublesex and mab-3 related transcription factor 1 (DMRT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001101831.1

ORF Insert Sequence:

ATGTGGCGGG ACTGCCAGTG CAAGAAGTGC AGCCTGATCG CCGAGCGGCA GCGGGTGATG 
GCCGCGCAGG TTGCACTGAG GAGGCAGCAA GCCCAGGAAG AGGAGCTGGG GATCAGCCAC 
CCTGTACCCC TGCCCAGTGC CCCTGAGCCA GTTGTCAAGA AGAGCAGCAG CAGCAGCTCC 
TGTCTCCTGC GGGACAGCAG CAGCCCTGCT CACTCCACGA GCACGGTGGC AGCAGCAGCA 
GCGAGCGCAC CACCAGGCCA GTGCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DMRT1 is required for M?llerian duct formation in the chicken embryo.
Developmental biology400(2)224-36(2015 Apr)
Ayers KL,Cutting AD,Roeszler KN,Sinclair AH,Smith CA

Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads.
Developmental biology389(2)160-72(2014 May)
Lambeth LS,Raymond CS,Roeszler KN,Kuroiwa A,Nakata T,Zarkower D,Smith CA

Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing gonads and Mullerian ducts.
Poultry science93(4)953-8(2014 Apr)
Omotehara T,Smith CA,Mantani Y,Kobayashi Y,Tatsumi A,Nagahara D,Hashimoto R,Hirano T,Umemura Y,Yokoyama T,Kitagawa H,Hoshi N

Temporospatial expression of Dmrt1 in chicken urogenital system (Gallus gallus) using whole mount in situ hybridization.
Acta biologica Hungarica64(2)161-8(2013 Jun)
Yang Y,Gong P,Feng YP,Li SJ,Peng XL,Ran ZP,Qian YG,Gong YZ

The avian Z-linked gene DMRT1 is required for male sex determination in the chicken.
Nature461(7261)267-71(2009 Sep)
Smith CA,Roeszler KN,Ohnesorg T,Cummins DM,Farlie PG,Doran TJ,Sinclair AH

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DMRT1 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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