MBD2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	MBD2
Entrez Gene ID	497269
Full Name	methyl-CpG binding domain protein 2
General protein information	Preferred Names methyl-CpG binding domain protein 2 Names methyl-CpG-binding domain protein 2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012403.1	NP_001012403.1	methyl-CpG-binding domain protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MBD2	XP_512139.4
Danio rerio (zebrafish)	mbd2	NP_997933.1
Homo sapiens (human)	MBD2	NP_003918.1
Bos taurus (cattle)	MBD2	XP_002697814.1
Rattus norvegicus (Norway rat)	Mbd2	NP_001108497.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003982	XP_003436675.1
	MBD2	XP_001082249.1
Mus musculus (house mouse)	Mbd2	NP_034903.2
Gallus gallus (chicken)	MBD2	NP_001012403.1
Canis lupus familiaris (dog)	MBD2	XP_005615735.1
Drosophila melanogaster (fruit fly)	MBD-like	NP_731370.1

Gene Ontology
Bibliography

Related articles in PubMed

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level.
Pan H, Bilinovich SM, Kaur P, Riehn R, Wang H, Williams DC Jr
Nucleic acids research45(15)9164-9177(2017 Sep)

Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.
Cramer JM, Scarsdale JN, Walavalkar NM, Buchwald WA, Ginder GD, Williams DC Jr
The Journal of biological chemistry289(3)1294-302(2014 Jan)

MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.
Kransdorf EP, Wang SZ, Zhu SZ, Langston TB, Rupon JW, Ginder GD
Blood108(8)2836-45(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CpG and methylation-dependent DNA binding and dynamics of the MBD2 protein at the single-molecule level have been reported.
Title: CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level.

these data establish the structural basis for the relative distribution of MBD2 and MBD3 on genomic DNA and their observed occupancy at active and inactive CpG-rich promoters.
Title: Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.

MBD2 binds to the methylated and transcriptionally silent rho-globin gene in vivo
Title: MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.

The following MBD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MBD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00293	NM_001012403.1 Latest version!	Gallus gallus methyl-CpG binding domain protein 2 (MBD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MBD2 ( NM_001012403.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001012403.1 Gallus gallus methyl-CpG binding domain protein 2 (MBD2), mRNA.

Price & Availability↑

CloneID	OGa00293
Clone ID Related Accession (Same CDS sequence)	NM_001012403.1
Accession Version	NM_001012403.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	methyl-CpG-binding domain protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY888006.1. ##Evidence-Data-START## Transcript exon combination :: AY888006.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATAAAC AGGGCAGGAC GGACTGCCCG GCCCTTCCAC CGGGTTGGAA GAAAGAAGAG 
GTGATCCGTA AGTCGGGTTT AAGCGCAGGC AAAAGCGACG TGTATTACTT CAGTCCGAGC 
GGGAAGAAGT TCCGAAGCAA ACCTCAACTT GCCCGTTATT TGGGGAACGC CGTGGATTTG 
AGTTGTTTCG ATTTCCGCAC GGGCAAAATG ATGCCGAGTA AATTACAGAA GAATAAACAG 
AGATTGAGGA ACGAATCGCT TCATCCCAAT AAGGGCAAAC CGGATCTCAA CACGGCCCTC 
CCCATCCGGC AGACGGCGTC CATCTTTAAG CAACCCGTCA CCAAAGTCAC CAACCACCCC 
GACAACAAAG TCCGTTCCGA CCCACAACGC CTCGCAGACC AACCCCGCCA GCTCTTCTGG 
GAGAAACGAC TTCGGGGTCT GAGCGCTTCC GATGTGGGGC AGGAGATCCT CCGGGCTATG 
GAGCTGCCCA GGGGGCTGCA AGCCCTTGGT CCCGTCCCGG ACGACGTCAC TTTGCTATCG 
GCCGTCGCCA GCGCTCTCCA TGTCGGTTCT GTTCCCGTTA CCGGACAGCT TTCGAGTGCT 
GCAGAGAAGA ATCCGGCGGT GTGGCTCAAT TCTTCCCAAC CTCTTTGCAG AGCTTTCGTT 
GTCACCGACG ACGACATCCG GAAGCAAGAG GAGCGGGTGA GGCGCGTGAG GAAGAAACTG 
GAAGAAGCAC TTCTGGCCGG CGACCCGGCG GGGTCACGGG GTCAAGACGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012403.1
CDS	6..779
Translation	MDKQGRTDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSCFDFRTGKMMPSKLQKNKQRLRNESLHPNKGKPDLNTALPIRQTASIFKQPVTKVTNHPDNKVRSDPQRLADQPRQLFWEKRLRGLSASDVGQEILRAMELPRGLQALGPVPDDVTLLSAVASALHVGSVPVTGQLSSAAEKNPAVWLNSSQPLCRAFVVTDDDIRKQEERVRRVRKKLEEALLAGDPAGSRGQDE

Target ORF information:

RefSeq Version	NM_001012403.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus methyl-CpG binding domain protein 2 (MBD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012403.1

ORF Insert Sequence:

ATGGATAAAC AGGGCAGGAC GGACTGCCCG GCCCTTCCAC CGGGTTGGAA GAAAGAAGAG 
GTGATCCGTA AGTCGGGTTT AAGCGCAGGC AAAAGCGACG TGTATTACTT CAGTCCGAGC 
GGGAAGAAGT TCCGAAGCAA ACCTCAACTT GCCCGTTATT TGGGGAACGC CGTGGATTTG 
AGTTGTTTCG ATTTCCGCAC GGGCAAAATG ATGCCGAGTA AATTACAGAA GAATAAACAG 
AGATTGAGGA ACGAATCGCT TCATCCCAAT AAGGGCAAAC CGGATCTCAA CACGGCCCTC 
CCCATCCGGC AGACGGCGTC CATCTTTAAG CAACCCGTCA CCAAAGTCAC CAACCACCCC 
GACAACAAAG TCCGTTCCGA CCCACAACGC CTCGCAGACC AACCCCGCCA GCTCTTCTGG 
GAGAAACGAC TTCGGGGTCT GAGCGCTTCC GATGTGGGGC AGGAGATCCT CCGGGCTATG 
GAGCTGCCCA GGGGGCTGCA AGCCCTTGGT CCCGTCCCGG ACGACGTCAC TTTGCTATCG 
GCCGTCGCCA GCGCTCTCCA TGTCGGTTCT GTTCCCGTTA CCGGACAGCT TTCGAGTGCT 
GCAGAGAAGA ATCCGGCGGT GTGGCTCAAT TCTTCCCAAC CTCTTTGCAG AGCTTTCGTT 
GTCACCGACG ACGACATCCG GAAGCAAGAG GAGCGGGTGA GGCGCGTGAG GAAGAAACTG 
GAAGAAGCAC TTCTGGCCGG CGACCCGGCG GGGTCACGGG GTCAAGACGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level.
Nucleic acids research45(15)9164-9177(2017 Sep)
Pan H,Bilinovich SM,Kaur P,Riehn R,Wang H,Williams DC Jr

Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.
The Journal of biological chemistry289(3)1294-302(2014 Jan)
Cramer JM,Scarsdale JN,Walavalkar NM,Buchwald WA,Ginder GD,Williams DC Jr

MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells.
Blood108(8)2836-45(2006 Oct)
Kransdorf EP,Wang SZ,Zhu SZ,Langston TB,Rupon JW,Ginder GD

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MBD2 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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