NOG cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	NOG
Entrez Gene ID	373912
Full Name	noggin
General protein information	Preferred Names noggin Names noggin cNoggin
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204123.1	NP_989454.1	noggin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NOG	NP_005441.1
Rattus norvegicus (Norway rat)	Nog	NP_037122.1
Danio rerio (zebrafish)	nog1	NP_571058.2
Gallus gallus (chicken)	NOG	NP_989454.1
Danio rerio (zebrafish)	nog3	NP_571057.1
Xenopus tropicalis (tropical clawed frog)	nog	NP_001165369.1
Pan troglodytes (chimpanzee)	NOG	XP_523802.2
	NOG	XP_001104355.1
Canis lupus familiaris (dog)	NOG	XP_005625045.1
Danio rerio (zebrafish)	LOC100333103	XP_002664025.1
Bos taurus (cattle)	NOG	XP_002695600.1
Mus musculus (house mouse)	Nog	NP_032737.1

Gene Ontology
Bibliography

Related articles in PubMed

Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells.
Tsai MS, Suksaweang S, Jiang TX, Wu P, Kao YH, Lee PH, Widelitz R, Chuong CM
Digestive diseases and sciences60(12)3669-80(2015 Dec)

Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Lorda-Diez CI, Montero JA, Choe S, Garcia-Porrero JA, Hurle JM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(3)735-48(2014 Mar)

The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle.
Notarnicola C, Rouleau C, Le Guen L, Virsolvy A, Richard S, Faure S, De Santa Barbara P
Gastroenterology143(3)687-697.e9(2012 Sep)

Noggin producing, MyoD-positive cells are crucial for eye development.
Gerhart J, Pfautz J, Neely C, Elder J, DuPrey K, Menko AS, Knudsen K, George-Weinstein M
Developmental biology336(1)30-41(2009 Dec)

Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest.
Os?rio L, Teillet MA, Catala M
Development (Cambridge, England)136(10)1717-26(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Noggin overexpression resulted in disrupted cord organization, and dilated sinusoidal space, eventually leading to increased apoptosis and failed hepatocyte differentiation.
Title: Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells.

The expression level of Noggin (together with other cartilage expressed BMP antagonists) is a landmark in the transition between the chondrogenic and fibrogenic response to BMPs in the differentiation of connective tissues.
Title: Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.

Study demonstrates that MyoD expressing cells serve as a Noggin delivery system to regulate the morphogenesis of the lens and optic cup.
Title: Noggin producing, MyoD-positive cells are crucial for eye development.

increased Bmp4-Wnt1 signaling through Nog inhibition in the caudal-most NT at E4/HH24 induces proneurogenic markers in migratory NCCs, suggesting that noggin plays a role in the lack of neurogenic potential characterizing the caudal-most NCCs.
Title: Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest.

In Noggin -/- embryos, the gross anatomy of the inner ear is distorted and malformed, with cochlear duct outgrowth and coiling most affected.
Title: Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice.

The following NOG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00364	NM_204123.1 Latest version!	Gallus gallus noggin (NOG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NOG ( NM_204123.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989454.1 Gallus gallus noggin (NOG), mRNA.

Price & Availability↑

CloneID	OGa00364
Clone ID Related Accession (Same CDS sequence)	NM_204123.1
Accession Version	NM_204123.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Gallus gallus(chicken)
Product	noggin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF057364.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF057364.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATCATT CCCAGTGCCT TGTGACTATA TACGCCGCGG CGGTGCTGCT GGGGCTCCGG 
CTGCAGCAGG GCTCCTGCCA GCACTACCTG CACATCCGCC CGGCTCCCAG CGACAACCTG 
CCCCTGGTGG ATCTAATCGA GCACCCGGAC CCTATCTTTG ACCCCAAGGA GAAGGATCTT 
AACGAGACCT TGCTAAGGAG CCTCATGGGA GGACACTTCG ACCCTAACTT TATGGCTATG 
TCCCTGCCCG AGGACCGGCT CGGGGTAGAC GATCTGGCCG AGCTGGACTT GCTGCTGCGG 
CAGAGACCCT CGGGAGCGAT GCCCGGCGAA ATCAAGGGGC TGGAGTTCTA CGACGGGCTG 
CAGCCGGGCA AGAAGCACAG GCTGAGCAAG AAGCTGCGCA GGAAGCTGCA GATGTGGCTC 
TGGTCCCAGA CCTTCTGCCC GGTCCTATAC ACGTGGAACG ATCTCGGCAG CCGCTTTTGG 
CCCCGGTACG TCAAAGTGGG CAGCTGCTAC AGTAAAAGGT CTTGCTCTGT CCCAGAAGGC 
ATGGTCTGCA AACCTGCCAA GTCCGTGCAT TTAACGATCC TGAGGTGGCG GTGCCAGCGG 
CGGGGCGGGC AGCGGTGCAC GTGGATCCCC ATCCAGTACC CCATCATCGC GGAGTGCAAG 
TGCTCCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989454.1
CDS	1..672
Translation	MDHSQCLVTIYAAAVLLGLRLQQGSCQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLMGGHFDPNFMAMSLPEDRLGVDDLAELDLLLRQRPSGAMPGEIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSKRSCSVPEGMVCKPAKSVHLTILRWRCQRRGGQRCTWIPIQYPIIAECKCSC

Target ORF information:

RefSeq Version	NM_204123.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus noggin (NOG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204123.1

ORF Insert Sequence:

ATGGATCATT CCCAGTGCCT TGTGACTATA TACGCCGCGG CGGTGCTGCT GGGGCTCCGG 
CTGCAGCAGG GCTCCTGCCA GCACTACCTG CACATCCGCC CGGCTCCCAG CGACAACCTG 
CCCCTGGTGG ATCTAATCGA GCACCCGGAC CCTATCTTTG ACCCCAAGGA GAAGGATCTT 
AACGAGACCT TGCTAAGGAG CCTCATGGGA GGACACTTCG ACCCTAACTT TATGGCTATG 
TCCCTGCCCG AGGACCGGCT CGGGGTAGAC GATCTGGCCG AGCTGGACTT GCTGCTGCGG 
CAGAGACCCT CGGGAGCGAT GCCCGGCGAA ATCAAGGGGC TGGAGTTCTA CGACGGGCTG 
CAGCCGGGCA AGAAGCACAG GCTGAGCAAG AAGCTGCGCA GGAAGCTGCA GATGTGGCTC 
TGGTCCCAGA CCTTCTGCCC GGTCCTATAC ACGTGGAACG ATCTCGGCAG CCGCTTTTGG 
CCCCGGTACG TCAAAGTGGG CAGCTGCTAC AGTAAAAGGT CTTGCTCTGT CCCAGAAGGC 
ATGGTCTGCA AACCTGCCAA GTCCGTGCAT TTAACGATCC TGAGGTGGCG GTGCCAGCGG 
CGGGGCGGGC AGCGGTGCAC GTGGATCCCC ATCCAGTACC CCATCATCGC GGAGTGCAAG 
TGCTCCTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells.
Digestive diseases and sciences60(12)3669-80(2015 Dec)
Tsai MS,Suksaweang S,Jiang TX,Wu P,Kao YH,Lee PH,Widelitz R,Chuong CM

Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(3)735-48(2014 Mar)
Lorda-Diez CI,Montero JA,Choe S,Garcia-Porrero JA,Hurle JM

The RNA-binding protein RBPMS2 regulates development of gastrointestinal smooth muscle.
Gastroenterology143(3)687-697.e9(2012 Sep)
Notarnicola C,Rouleau C,Le Guen L,Virsolvy A,Richard S,Faure S,De Santa Barbara P

Noggin producing, MyoD-positive cells are crucial for eye development.
Developmental biology336(1)30-41(2009 Dec)
Gerhart J,Pfautz J,Neely C,Elder J,DuPrey K,Menko AS,Knudsen K,George-Weinstein M

Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest.
Development (Cambridge, England)136(10)1717-26(2009 May)
Os?rio L,Teillet MA,Catala M

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NOG cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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