bmper cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	bmper
Entrez Gene ID	338246
Full Name	BMP binding endothelial regulator
Synonyms	cvl2,id:ibd5071
General protein information	Preferred Names BMP binding endothelial regulator Names BMP-binding endothelial regulator protein crossveinless 2 cv2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001020487.2	NP_001018323.2	BMP-binding endothelial regulator protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BMPER	XP_519036.3
Mus musculus (house mouse)	Bmper	NP_082748.1
Danio rerio (zebrafish)	bmper	NP_001018323.1
Rattus norvegicus (Norway rat)	Bmper	NP_001129271.1
Drosophila melanogaster (fruit fly)	cv-2	NP_524809.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006168	XP_316228.4
Homo sapiens (human)	BMPER	NP_597725.1
	BMPER	XP_001105988.1
Gallus gallus (chicken)	BMPER	NP_001007081.1
Canis lupus familiaris (dog)	BMPER	XP_532513.2
Bos taurus (cattle)	BMPER	NP_001071465.1
Xenopus tropicalis (tropical clawed frog)	bmper	NP_001037867.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.
Ben-Moshe Livne Z, Alon S, Vallone D, Bayleyen Y, Tovin A, Shainer I, Nisembaum LG, Aviram I, Smadja-Storz S, Fuentes M, Falc?n J, Eisenberg E, Klein DC, Burgess HA, Foulkes NS, Gothilf Y
PLoS genetics12(11)e1006445(2016 Nov)

Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.
Kok FO, Shin M, Ni CW, Gupta A, Grosse AS, van Impel A, Kirchmaier BC, Peterson-Maduro J, Kourkoulis G, Male I, DeSantis DF, Sheppard-Tindell S, Ebarasi L, Betsholtz C, Schulte-Merker S, Wolfe SA, Lawson ND
Developmental cell32(1)97-108(2015 Jan)

Dissecting the differentiation process of the preplacodal ectoderm in zebrafish.
Yao D, Zhao F, Wu Y, Wang J, Dong W, Zhao J, Zhu Z, Liu D
Developmental dynamics : an official publication of the American Association of Anatomists243(10)1338-51(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.
Title: A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border.

The NMR structure of the Danio rerio CV2 VWC1 domain in its unbound state shows the key features for high affinity binding to BMP-2 are a pre-oriented peptide loop.
Title: The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.

LRP1 acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 to mediate the endocytosis of the Bmper/Bmp4 signaling complex.
Title: LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.

Binding of CV2 to Chordin promotes BMP-2 signaling.
Title: Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity.

The structure of the complex between CV-2 Von Willebrand factor type C (VWC) domain 1 and BMP-2, is reported.
Title: Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding.

The following bmper gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the bmper cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa40131	NM_001020487.2 Latest version!	Danio rerio BMP binding endothelial regulator (bmper), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

bmper ( NM_001020487.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001018323.2 Danio rerio BMP binding endothelial regulator (bmper), mRNA.

Price & Availability↑

CloneID	ODa40131
Clone ID Related Accession (Same CDS sequence)	NM_001020487.2
Accession Version	NM_001020487.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2007bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-18
Organism	Danio rerio(zebrafish)
Product	BMP-binding endothelial regulator protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC146642.1. On Jun 18, 2015 this sequence version replaced NM_001020487.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC146642.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGCTGTGTC TGTCTCCTCC AGTAACCTAC AACCTGTTAT TCTGGTTTTT AATTCTCCAA 
ACGCCACAAT CAACTGCACC TTTAATCACC GGTACAGAGG CTAGCTGTGA AAACGAGGGA 
GAAGTGTTAC ACATCCCCAA CATCACAGAC AACCCCTGCA TCTCCTGCGT CTGTCTGAAT 
CAGAAAGCGG AGTGTAAGCA GGAGAAGTGT GCACCGCTGG CAGAGGACTG TGCACTGGTG 
GTCAAACAGA CGGGAGCCTG CTGTGAAAAA TGCAAAGGTT GTCTTCTGAA AGGGACGTCC 
TACAACAGTT CCCATCACTG GATAAGCCCT GTGAAACCCT GTGTCACGTA CAGCTGTCAG 
GAAGGTGTCA TCACTGAAGC AGAGATGAGG TGTGTCATTC ACTGTAAGAA CCCTAAAATC 
CACCCCAAGA AATGCTGCCC TACATGTCCA GGGTGCATTT TTGAGGGGAA TTTATATAAA 
GAAGATGAAG AATTTCACCC TGAAGGGAAT CCCTGTATTA AATGCGTCTG CACTGGAGGG 
CAAAGCATGT GTCATAAATT GGTGTGTCCT GTTCTGTCCT GCCCGTCTCA TCTTACCCAC 
ACTCCACCTG GCCAGTGCTG TCCAAGATGT CGGGGTCAGA GGAGGGTGTT TGACTTATCG 
CCGGGCAGCT GTTTGTTCCA TAGTGAGGTT TATGAGAACG GCTCCTCTAT CAGCTATGAT 
AACTGCACCA CCTGCACCTG TGTGGACTCC ACAGTGCTCT GCAGGAAGAG ATGCTCTCCG 
CCTGGCAGCT GTCATGGCAC TGCCTGCTGC GAAGCCTGCC AGTCTCACCT CAAGATGGAA 
GACGTGAAAT ACTGCAGAGT CAAGAGCAAA ATCTATAGGG ATGGCGACAG ATGGTCGTCT 
GTGAACTGTT CTCTGTGCAC GTGCGTTAAA GGGAATATTC AATGTCAGCC TAAGATTTGC 
GTTCCTATCA CCAGCTGTCC CTCGAATAAG ATACTGAATC GCACTGGCTG CTGTCCTGTT 
TGCACTGACA AGCCAGGCGT GTGTACCGTA TTTGGAGACC CTCACTATAA CACTTTTGAC 
GGCCGTACCT TCAACTTCCA GGGCACGTGT AAATATGTGC TCACCAAGGA CTGTTCCCCA 
GCGGCCAGCT TCACAGTGCT TGTGAAGAAC GATGCCCGAC GCACACGTTC CTTCTCATGG 
ACCAAATCAG TGGAGCTGCA CACGTCCGGC CTGAGCATCA GCCTTCACCA ACACCTGACC 
GTCCGGCAGA ACGGCACACG CATCGCTCTT CCCTTCCACA GCACCGGCGT CCACATCGAC 
CTGGATGGAT ACCTGCTCAA ACTCACCACC ATCGCAGGAC TGGAGATCAC GTGGGATGGG 
GACAGTCTGG TGGAGGTGGT CGCAGCGCCT CATCTGAAGG GGCAGCTGTG TGGTCTTTGT 
GGAAACTACA ACGGTCAGCG GCGAGACGAC TCTCTTGGAG GAGACGGACA GTTTAAGTTT 
GACGTGGATG AACTTGCTGA ATCGTGGCGT GTGGAGGACA ACGAGCTGTG CGAAGTACAG 
AACCGCCGGC CCACATCCTT TCTCTGTGCC GGAACAGTCA AGGTGAAGCT CCGCGCTCAC 
AGAACCTGCC AGAAGCTCAA GTCCTGGGAG TTTCAGAAGT GCCACTCTGC TGTCGACTTT 
ACCTCCTTTT ACAAGTCGTG TGTAACAGAC ATGTGTGAGT GTCCAGTGCA TAAGAACTGT 
TTCTGTGAGT CCTTCATAGC GTACAGTCGA GCCTGTGAGA GAGAAGGGAT TCATGTGCAC 
TGGAGACCAG AGCTCACCTG CATGAGCACA CATTGCAAAC ACGGCGCAGT TTATGACACA 
TGTGGGCCTG GCTGCACTAA AAGCTGCCAT AACTGGAATG AAATCGGACC CTGTCAGAGG 
CCCTGCATCG CCGGCTGCCA CTGTCCCGCC AGCCTGGTCA TGTTTCAGGG CCACTGCATT 
AAACCAACAT CCTGCCCCGG GCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018323.2
CDS	456..2462
Translation	MLCLSPPVTYNLLFWFLILQTPQSTAPLITGTEASCENEGEVLHIPNITDNPCISCVCLNQKAECKQEKCAPLAEDCALVVKQTGACCEKCKGCLLKGTSYNSSHHWISPVKPCVTYSCQEGVITEAEMRCVIHCKNPKIHPKKCCPTCPGCIFEGNLYKEDEEFHPEGNPCIKCVCTGGQSMCHKLVCPVLSCPSHLTHTPPGQCCPRCRGQRRVFDLSPGSCLFHSEVYENGSSISYDNCTTCTCVDSTVLCRKRCSPPGSCHGTACCEACQSHLKMEDVKYCRVKSKIYRDGDRWSSVNCSLCTCVKGNIQCQPKICVPITSCPSNKILNRTGCCPVCTDKPGVCTVFGDPHYNTFDGRTFNFQGTCKYVLTKDCSPAASFTVLVKNDARRTRSFSWTKSVELHTSGLSISLHQHLTVRQNGTRIALPFHSTGVHIDLDGYLLKLTTIAGLEITWDGDSLVEVVAAPHLKGQLCGLCGNYNGQRRDDSLGGDGQFKFDVDELAESWRVEDNELCEVQNRRPTSFLCAGTVKVKLRAHRTCQKLKSWEFQKCHSAVDFTSFYKSCVTDMCECPVHKNCFCESFIAYSRACEREGIHVHWRPELTCMSTHCKHGAVYDTCGPGCTKSCHNWNEIGPCQRPCIAGCHCPASLVMFQGHCIKPTSCPGR

Target ORF information:

RefSeq Version	NM_001020487.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio BMP binding endothelial regulator (bmper), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001020487.2

ORF Insert Sequence:

ATGCTGTGTC TGTCTCCTCC AGTAACCTAC AACCTGTTAT TCTGGTTTTT AATTCTCCAA 
ACGCCACAAT CAACTGCACC TTTAATCACC GGTACAGAGG CTAGCTGTGA AAACGAGGGA 
GAAGTGTTAC ACATCCCCAA CATCACAGAC AACCCCTGCA TCTCCTGCGT CTGTCTGAAT 
CAGAAAGCGG AGTGTAAGCA GGAGAAGTGT GCACCGCTGG CAGAGGACTG TGCACTGGTG 
GTCAAACAGA CGGGAGCCTG CTGTGAAAAA TGCAAAGGTT GTCTTCTGAA AGGGACGTCC 
TACAACAGTT CCCATCACTG GATAAGCCCT GTGAAACCCT GTGTCACGTA CAGCTGTCAG 
GAAGGTGTCA TCACTGAAGC AGAGATGAGG TGTGTCATTC ACTGTAAGAA CCCTAAAATC 
CACCCCAAGA AATGCTGCCC TACATGTCCA GGGTGCATTT TTGAGGGGAA TTTATATAAA 
GAAGATGAAG AATTTCACCC TGAAGGGAAT CCCTGTATTA AATGCGTCTG CACTGGAGGG 
CAAAGCATGT GTCATAAATT GGTGTGTCCT GTTCTGTCCT GCCCGTCTCA TCTTACCCAC 
ACTCCACCTG GCCAGTGCTG TCCAAGATGT CGGGGTCAGA GGAGGGTGTT TGACTTATCG 
CCGGGCAGCT GTTTGTTCCA TAGTGAGGTT TATGAGAACG GCTCCTCTAT CAGCTATGAT 
AACTGCACCA CCTGCACCTG TGTGGACTCC ACAGTGCTCT GCAGGAAGAG ATGCTCTCCG 
CCTGGCAGCT GTCATGGCAC TGCCTGCTGC GAAGCCTGCC AGTCTCACCT CAAGATGGAA 
GACGTGAAAT ACTGCAGAGT CAAGAGCAAA ATCTATAGGG ATGGCGACAG ATGGTCGTCT 
GTGAACTGTT CTCTGTGCAC GTGCGTTAAA GGGAATATTC AATGTCAGCC TAAGATTTGC 
GTTCCTATCA CCAGCTGTCC CTCGAATAAG ATACTGAATC GCACTGGCTG CTGTCCTGTT 
TGCACTGACA AGCCAGGCGT GTGTACCGTA TTTGGAGACC CTCACTATAA CACTTTTGAC 
GGCCGTACCT TCAACTTCCA GGGCACGTGT AAATATGTGC TCACCAAGGA CTGTTCCCCA 
GCGGCCAGCT TCACAGTGCT TGTGAAGAAC GATGCCCGAC GCACACGTTC CTTCTCATGG 
ACCAAATCAG TGGAGCTGCA CACGTCCGGC CTGAGCATCA GCCTTCACCA ACACCTGACC 
GTCCGGCAGA ACGGCACACG CATCGCTCTT CCCTTCCACA GCACCGGCGT CCACATCGAC 
CTGGATGGAT ACCTGCTCAA ACTCACCACC ATCGCAGGAC TGGAGATCAC GTGGGATGGG 
GACAGTCTGG TGGAGGTGGT CGCAGCGCCT CATCTGAAGG GGCAGCTGTG TGGTCTTTGT 
GGAAACTACA ACGGTCAGCG GCGAGACGAC TCTCTTGGAG GAGACGGACA GTTTAAGTTT 
GACGTGGATG AACTTGCTGA ATCGTGGCGT GTGGAGGACA ACGAGCTGTG CGAAGTACAG 
AACCGCCGGC CCACATCCTT TCTCTGTGCC GGAACAGTCA AGGTGAAGCT CCGCGCTCAC 
AGAACCTGCC AGAAGCTCAA GTCCTGGGAG TTTCAGAAGT GCCACTCTGC TGTCGACTTT 
ACCTCCTTTT ACAAGTCGTG TGTAACAGAC ATGTGTGAGT GTCCAGTGCA TAAGAACTGT 
TTCTGTGAGT CCTTCATAGC GTACAGTCGA GCCTGTGAGA GAGAAGGGAT TCATGTGCAC 
TGGAGACCAG AGCTCACCTG CATGAGCACA CATTGCAAAC ACGGCGCAGT TTATGACACA 
TGTGGGCCTG GCTGCACTAA AAGCTGCCAT AACTGGAATG AAATCGGACC CTGTCAGAGG 
CCCTGCATCG CCGGCTGCCA CTGTCCCGCC AGCCTGGTCA TGTTTCAGGG CCACTGCATT 
AAACCAACAT CCTGCCCCGG GCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.
PLoS genetics12(11)e1006445(2016 Nov)
Ben-Moshe Livne Z,Alon S,Vallone D,Bayleyen Y,Tovin A,Shainer I,Nisembaum LG,Aviram I,Smadja-Storz S,Fuentes M,Falc?n J,Eisenberg E,Klein DC,Burgess HA,Foulkes NS,Gothilf Y

Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish.
Developmental cell32(1)97-108(2015 Jan)
Kok FO,Shin M,Ni CW,Gupta A,Grosse AS,van Impel A,Kirchmaier BC,Peterson-Maduro J,Kourkoulis G,Male I,DeSantis DF,Sheppard-Tindell S,Ebarasi L,Betsholtz C,Schulte-Merker S,Wolfe SA,Lawson ND

Dissecting the differentiation process of the preplacodal ectoderm in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists243(10)1338-51(2014 Oct)
Yao D,Zhao F,Wu Y,Wang J,Dong W,Zhao J,Zhu Z,Liu D

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bmper cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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