MPC2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.
Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S
Science (New York, N.Y.)265(5181)2077-82(1994 Sep)

while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.

study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
Title: Identification and functional expression of the mitochondrial pyruvate carrier.

Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier
Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.