SLM1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	SLM1
Entrez Gene ID	854701
Full Name	phosphatidylinositol 4,5-bisphosphate-binding protein
Synonyms	LIT2
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001179453.1	NP_012161.1	phosphatidylinositol 4,5-bisphosphate-binding protein

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	SLM1	NP_012161.1
Kluyveromyces lactis	KLLA0F03839g	XP_455254.1
Eremothecium gossypii	AGOS_ADL234C	NP_983862.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B
Nature387(6632 Suppl)84-7(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Slm1/Slm2 and TORC2-dependent phosphorylation of Ypk1 is coupled to the biosynthesis of complex sphingolipids and to their levels within the plasma membrane.
Title: Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae.

Slm proteins are required for proper eisosome organization, endocytic trafficking and recycling in the yeast Saccharomyces cerevisiae.
Title: Requirements of Slm proteins for proper eisosome organization, endocytic trafficking and recycling in the yeast Saccharomyces cerevisiae.

Slm proteins are subject to regulation by multiple signals, including PI4,5P(2), TORC2, and sphingolipids, and may thus integrate inputs from different signaling pathways to temporally and spatially control actin polarization
Title: The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress.

Data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization.
Title: The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.

calcineurin may modulate sphingolipid-dependent events through regulation of Slm1 and Slm2
Title: Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

The following SLM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi03737	NM_001179453.1 Latest version!	Saccharomyces cerevisiae S288C phosphatidylinositol 4,5-bisphosphate-binding protein (SLM1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLM1 ( NM_001179453.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_012161.1 Saccharomyces cerevisiae S288C phosphatidylinositol 4,5-bisphosphate-binding protein (SLM1), partial mRNA.

Price & Availability↑

CloneID	OSi03737
Clone ID Related Accession (Same CDS sequence)	NM_001179453.1
Accession Version	NM_001179453.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	phosphatidylinositol 4,5-bisphosphate-binding protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001141). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGTCGAAAA ACAACACAAT GACCTCTGCG GTCTCTGATA TGCTGTCACA GCAACAGCTA 
AATCTTCAGC ACCTGCATAA CTTGCAGCAG CATACGAGAA GTATGACTTC AGCAGATCAT 
GCCAACGTTT TACAACAACA GCAACAACAA CAACAACAAC AACAGCAGCA GCAGCAGCAA 
CAGCAGCAGA GCGCAAGCTT TCAAAATGGC AGTTTGACAT CCGATATAAA CCAACAAAGC 
TATTTGAATG GACAACCAGT TCCTTCCACT AGTAATTCAA CGTTTCAAAA CAATAGGACG 
CTGACGATGA ATTCTGGAGG GTTGCAAGGT ATCATAAGCA ATGGTTCTCC TAATATCGAC 
TCGAACACCA ATGTAACCAT TGCTGTCCCA GATCCCAATA ATAACAACGG GAAACAGCTC 
CAAGGGAAAA ACTCTTTAAC CAACACTTCA ATACTGTCGA GGGCTAGGTC TTCCTTACAA 
CGTCAAAGAC TTGCTCAGCA ACAGCAACAA CAACAAGATC CTAGATCTCC ATTAGTAATA 
CTGGTCCCTA CAGCTGCGCA ACCAACAGAT ATTCTTGCAG CGAGGTTTTC AGCTTGGAGA 
AATGTCATCA AGTCGGTGAT CGTTTACTTA ACAGAAATCG CTTCTATTCA GGATGAAATT 
GTTAGACAGC AACTAAGATT ATCACATGCT GTACAATTCC CATTCTTTTC GATCGAGAAT 
CAATACCAAC CAAGCTCGCA GGAGGATAAA TCAGTACAAA AGTTTTTTTT GCCATTGGGT 
AATGGCTCGA TACAGGACTT ACCAACAATT TTGAACCAGT ATCATGAATC CCTAGCATCC 
AGCGCGTCTA AGGCATCAAG GGAATTGACC AATGATGTTA TTCCTCGTTT GGAAGACTTG 
AGGAGAGATC TAATAGTCAA GATAAAGGAA ATAAAATCAC TGCAGTCGGA TTTCAAAAAT 
TCTTGTTCCA AAGAGTTACA ACAAACAAAA CAGGCCATGA AGCAATTTCA GGAGTCTTTA 
AAGGATGCGC GCTATTCAGT GCCAAAACAA GATCCATTCT TAACCAAGCT GGCGCTTGAT 
AGACAAATTA AAAAGCAACT TCAGGAGGAA AACTTTCTGC ATGAAGCTTT TGATAATTTA 
GAGACTTCAG GCGCTGAATT AGAAAAAATT GTAGTTATGG AAATTCAAAA CTCTTTAACA 
ATATATGCCA GATTACTGGG ACAAGAAGCA CAATTGGTTT TCGATATATT GATATCCAAA 
TTAGATTCTG GATTTTTCAA CGTTGACCCA CAATTTGAAT GGGATAACTT CATTTCAAGG 
GATCCCAACT TTTTATTGCC TAATCTACCG ATGAGGACAT TCAAAGAAAT CGTTTACAAA 
TACCAATTCG ATCCTTTGAC TTATGAAATC AAATCAGGGT TTTTAGAAAG AAGATCAAAA 
TTTCTAAAAT CCTATTCAAA AGGGTATTAT GTGCTGACAC CGAACTTTTT ACATGAATTC 
AAGACCGCGG ACAGAAAAAA AGATTTAGTA CCAGTGATGT CGTTAGCATT AAGTGAATGT 
ACTGTGACGG AACATTCCCG GAAAAACAGT ACATCATCAC CAAATTCGAC TGGTTCGGAT 
GCTAAGTTTG TGTTGCATGC TAAGCAAAAC GGCATAATTC GTCGTGGTCA CAATTGGGTT 
TTTAAAGCCG ATTCTTATGA ATCAATGATG TCTTGGTTTG ATAATTTGAA GATCTTAACA 
TCTACTTCGA ATATACAAGA CAAGTATAAA TTCATAACAC AAAAATTAAA CTTGAATTCA 
GATGGGAAAC CCAAGCTAAC CAATAACCAT ACCAGCATTA ATAAGTATCA GCTGAGTAAT 
GCCAATAGCA CAATGGTAGA AAATGATGAA AACGATGATA TAAATAGTAA TTATGTGGGG 
TCCACGGTAA CACCAAAATT GGACAATCAA ACAAATACGA ATACATCCAT GTCTTCATTA 
CCTGATACTA ATGATTCTGA ATTACAAGAT CAAGTTCCCA ATATTTATAT TCAAACTCCA 
ATAAACGATT TCAAATCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_012161.1
CDS	1..2061
Translation	MSKNNTMTSAVSDMLSQQQLNLQHLHNLQQHTRSMTSADHANVLQQQQQQQQQQQQQQQQQQQSASFQNGSLTSDINQQSYLNGQPVPSTSNSTFQNNRTLTMNSGGLQGIISNGSPNIDSNTNVTIAVPDPNNNNGKQLQGKNSLTNTSILSRARSSLQRQRLAQQQQQQQDPRSPLVILVPTAAQPTDILAARFSAWRNVIKSVIVYLTEIASIQDEIVRQQLRLSHAVQFPFFSIENQYQPSSQEDKSVQKFFLPLGNGSIQDLPTILNQYHESLASSASKASRELTNDVIPRLEDLRRDLIVKIKEIKSLQSDFKNSCSKELQQTKQAMKQFQESLKDARYSVPKQDPFLTKLALDRQIKKQLQEENFLHEAFDNLETSGAELEKIVVMEIQNSLTIYARLLGQEAQLVFDILISKLDSGFFNVDPQFEWDNFISRDPNFLLPNLPMRTFKEIVYKYQFDPLTYEIKSGFLERRSKFLKSYSKGYYVLTPNFLHEFKTADRKKDLVPVMSLALSECTVTEHSRKNSTSSPNSTGSDAKFVLHAKQNGIIRRGHNWVFKADSYESMMSWFDNLKILTSTSNIQDKYKFITQKLNLNSDGKPKLTNNHTSINKYQLSNANSTMVENDENDDINSNYVGSTVTPKLDNQTNTNTSMSSLPDTNDSELQDQVPNIYIQTPINDFKS

Target ORF information:

RefSeq Version	NM_001179453.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C phosphatidylinositol 4,5-bisphosphate-binding protein (SLM1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001179453.1

ORF Insert Sequence:

ATGTCGAAAA ACAACACAAT GACCTCTGCG GTCTCTGATA TGCTGTCACA GCAACAGCTA 
AATCTTCAGC ACCTGCATAA CTTGCAGCAG CATACGAGAA GTATGACTTC AGCAGATCAT 
GCCAACGTTT TACAACAACA GCAACAACAA CAACAACAAC AACAGCAGCA GCAGCAGCAA 
CAGCAGCAGA GCGCAAGCTT TCAAAATGGC AGTTTGACAT CCGATATAAA CCAACAAAGC 
TATTTGAATG GACAACCAGT TCCTTCCACT AGTAATTCAA CGTTTCAAAA CAATAGGACG 
CTGACGATGA ATTCTGGAGG GTTGCAAGGT ATCATAAGCA ATGGTTCTCC TAATATCGAC 
TCGAACACCA ATGTAACCAT TGCTGTCCCA GATCCCAATA ATAACAACGG GAAACAGCTC 
CAAGGGAAAA ACTCTTTAAC CAACACTTCA ATACTGTCGA GGGCTAGGTC TTCCTTACAA 
CGTCAAAGAC TTGCTCAGCA ACAGCAACAA CAACAAGATC CTAGATCTCC ATTAGTAATA 
CTGGTCCCTA CAGCTGCGCA ACCAACAGAT ATTCTTGCAG CGAGGTTTTC AGCTTGGAGA 
AATGTCATCA AGTCGGTGAT CGTTTACTTA ACAGAAATCG CTTCTATTCA GGATGAAATT 
GTTAGACAGC AACTAAGATT ATCACATGCT GTACAATTCC CATTCTTTTC GATCGAGAAT 
CAATACCAAC CAAGCTCGCA GGAGGATAAA TCAGTACAAA AGTTTTTTTT GCCATTGGGT 
AATGGCTCGA TACAGGACTT ACCAACAATT TTGAACCAGT ATCATGAATC CCTAGCATCC 
AGCGCGTCTA AGGCATCAAG GGAATTGACC AATGATGTTA TTCCTCGTTT GGAAGACTTG 
AGGAGAGATC TAATAGTCAA GATAAAGGAA ATAAAATCAC TGCAGTCGGA TTTCAAAAAT 
TCTTGTTCCA AAGAGTTACA ACAAACAAAA CAGGCCATGA AGCAATTTCA GGAGTCTTTA 
AAGGATGCGC GCTATTCAGT GCCAAAACAA GATCCATTCT TAACCAAGCT GGCGCTTGAT 
AGACAAATTA AAAAGCAACT TCAGGAGGAA AACTTTCTGC ATGAAGCTTT TGATAATTTA 
GAGACTTCAG GCGCTGAATT AGAAAAAATT GTAGTTATGG AAATTCAAAA CTCTTTAACA 
ATATATGCCA GATTACTGGG ACAAGAAGCA CAATTGGTTT TCGATATATT GATATCCAAA 
TTAGATTCTG GATTTTTCAA CGTTGACCCA CAATTTGAAT GGGATAACTT CATTTCAAGG 
GATCCCAACT TTTTATTGCC TAATCTACCG ATGAGGACAT TCAAAGAAAT CGTTTACAAA 
TACCAATTCG ATCCTTTGAC TTATGAAATC AAATCAGGGT TTTTAGAAAG AAGATCAAAA 
TTTCTAAAAT CCTATTCAAA AGGGTATTAT GTGCTGACAC CGAACTTTTT ACATGAATTC 
AAGACCGCGG ACAGAAAAAA AGATTTAGTA CCAGTGATGT CGTTAGCATT AAGTGAATGT 
ACTGTGACGG AACATTCCCG GAAAAACAGT ACATCATCAC CAAATTCGAC TGGTTCGGAT 
GCTAAGTTTG TGTTGCATGC TAAGCAAAAC GGCATAATTC GTCGTGGTCA CAATTGGGTT 
TTTAAAGCCG ATTCTTATGA ATCAATGATG TCTTGGTTTG ATAATTTGAA GATCTTAACA 
TCTACTTCGA ATATACAAGA CAAGTATAAA TTCATAACAC AAAAATTAAA CTTGAATTCA 
GATGGGAAAC CCAAGCTAAC CAATAACCAT ACCAGCATTA ATAAGTATCA GCTGAGTAAT 
GCCAATAGCA CAATGGTAGA AAATGATGAA AACGATGATA TAAATAGTAA TTATGTGGGG 
TCCACGGTAA CACCAAAATT GGACAATCAA ACAAATACGA ATACATCCAT GTCTTCATTA 
CCTGATACTA ATGATTCTGA ATTACAAGAT CAAGTTCCCA ATATTTATAT TCAAACTCCA 
ATAAACGATT TCAAATCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Nature387(6632 Suppl)84-7(1997 May)
Churcher C,Bowman S,Badcock K,Bankier A,Brown D,Chillingworth T,Connor R,Devlin K,Gentles S,Hamlin N,Harris D,Horsnell T,Hunt S,Jagels K,Jones M,Lye G,Moule S,Odell C,Pearson D,Rajandream M,Rice P,Rowley N,Skelton J,Smith V,Barrell B

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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SLM1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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