Gene Symbol | HMG2 |
Entrez Gene ID | 851171 |
Full Name | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » HMG2 cDNA ORF clone
Gene Symbol | HMG2 |
Entrez Gene ID | 851171 |
Full Name | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182338.1 | NP_013555.1 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
Homo sapiens (human) | HMGCR | NP_000850.1 |
Gallus gallus (chicken) | HMGCR | NP_989816.1 |
Caenorhabditis elegans (roundworm) | hmgr-1 | NP_498626.2 |
Saccharomyces cerevisiae (baker's yeast) | HMG2 | NP_013555.1 |
Kluyveromyces lactis | KLLA0B04642g | XP_451740.1 |
Pan troglodytes (chimpanzee) | HMGCR | XP_001148405.2 |
Bos taurus (cattle) | HMGCR | NP_001099083.1 |
Xenopus tropicalis (tropical clawed frog) | hmgcr | XP_004910453.1 |
HMGCR | XP_002804463.1 | |
Canis lupus familiaris (dog) | HMGCR | XP_536323.3 |
Drosophila melanogaster (fruit fly) | Hmgcr | NP_732900.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08975 | XP_003714014.1 |
Neurospora crassa | NCU00712 | XP_964546.1 |
Arabidopsis thaliana (thale cress) | HMG1 | NP_177775.2 |
Oryza sativa (rice) | Os09g0492700 | NP_001063541.1 |
Oryza sativa (rice) | Os08g0512700 | NP_001062221.1 |
Mus musculus (house mouse) | Hmgcr | NP_032281.2 |
Rattus norvegicus (Norway rat) | Hmgcr | NP_037266.2 |
Danio rerio (zebrafish) | hmgcra | NP_001073446.1 |
Arabidopsis thaliana (thale cress) | HMG2 | NP_179329.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002288 | XP_307890.5 |
Saccharomyces cerevisiae (baker's yeast) | HMG1 | NP_013636.1 |
Eremothecium gossypii | AGOS_AER152W | NP_985010.2 |
Schizosaccharomyces pombe (fission yeast) | hmg1 | NP_588235.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nsg1-mediated stabilization of Hmg2 and the Nsg1-Hmg2 interaction required the early sterol lanosterol.
Title: Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.
The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.
Title: The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.
In the K6R substituted Hmg2 mutant, the squalene content was approximately 20-fold higher than in the wild-type EGY48 parental strain and ERG6 deletion did not further enhance squalene accumulation.
Title: Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6.
GGPP is the FPP-derived regulator of Hmg2p ubiquitination.
Title: Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.
Hrd1p was rate-limiting for Hmg2p-GFP retrotranslocation, which required ATP, the AAA-ATPase Cdc48p, and its receptor Ubx2p.
Title: In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase.
The following HMG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HMG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00762 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182338.1 | |
Accession Version | NM_001182338.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCACTTC CCTTAAAAAC GATAGTACAT TTGGTAAAGC CCTTTGCTTG CACTGCTAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013555.1 |
CDS | 1..3138 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182338.1 |
1 | ATGTCACTTC CCTTAAAAAC GATAGTACAT TTGGTAAAGC CCTTTGCTTG CACTGCTAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |