SMURF2 Antibody, mAb, Rabbit
SMURF2 Antibody, MAb, Rabbit

Western blot analysis of SMURF 2 expression in SH-SY-5Y cell lysate.

SMURF2 Antibody, mAb, Rabbit

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling.
A04205
¥37,309.00

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Overview
Specificity This product is specific to SMURF2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SMURF2
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated

Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000

Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal

Examples
  • SMURF2 Antibody, MAb, Rabbit
    • SMURF2 Antibody, MAb, Rabbit

    Western blot analysis of SMURF 2 expression in SH-SY-5Y cell lysate.


Background
Target Background E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling.
Synonyms hSMURF2; SMUF2_HUMAN; Smurf2;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.