VEGFB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VEGFB
Entrez Gene ID	7423
Full Name	vascular endothelial growth factor B
Synonyms	VEGFL,VRF
General protein information	Preferred Names vascular endothelial growth factor B Names vascular endothelial growth factor B VEGF-related factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011].
Disorder MIM:	601398

mRNA and Protein(s)

mRNA	Protein	Name
NM_003377.5	NP_003368.1	vascular endothelial growth factor B isoform VEGFB-186 precursor
NM_001243733.1	NP_001230662.1	vascular endothelial growth factor B isoform VEGFB-167 precursor
NM_003377.4	NP_003368.1	vascular endothelial growth factor B isoform VEGFB-186 precursor
NM_001243733.2	NP_001230662.1	vascular endothelial growth factor B isoform VEGFB-167 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	VEGFB	NP_001230662.1
Pan troglodytes (chimpanzee)	VEGFB	XP_001144738.2
Canis lupus familiaris (dog)	VEGFB	XP_533245.2
Rattus norvegicus (Norway rat)	Vegfb	NP_446001.1
	LOC722115	XP_001118308.1
Mus musculus (house mouse)	Vegfb	NP_001172093.1
Bos taurus (cattle)	VEGFB	XP_005227276.1

Gene Ontology
Bibliography

Related articles in PubMed

Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of ?-cell.
Wu J, Wei H, Qu H, Feng Z, Long J, Ge Q, Deng H
Journal of endocrinological investigation40(11)1219-1226(2017 Nov)

The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence.
Zafar MI, Zheng J, Kong W, Ye X, Gou L, Regmi A, Chen LL
Bioscience reports37(4)(2017 Aug)

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.
Falkevall A, Mehlem A, Palombo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg AJ, Olauson H, Axelsson J, Sundelin B, Patrakka J, Scotney P, Nash A, Eriksson U
Cell metabolism25(3)713-726(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury.
Title: Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury.

renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease.
Title: Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.

Data show that metformin treatment reduces serum vascular endothelial growth factor B (VEGF-B) levels and ameliorates insulin resistance.
Title: Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment.

plasma VEGF levels before treatment were lower in patients with schizophrenia and that their VEGF levels increased after treatment.
Title: Alterations in plasma vascular endothelial growth factor levels in patients with schizophrenia before and after treatment.

VEGFA and VEGFB associated sub-network, kinase insert domain receptor (KDR), fibronectin 1 (FN1), transforming growth factor beta induced (TGFBI) and proliferating cell nuclear antigen (PCNA) found to interact with at least two of the three hub genes.
Title: Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer.

The following VEGFB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VEGFB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07719	NM_001243733.2 Latest version!	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21835	NM_003377.5 Latest version!	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21835	NM_003377.4	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07719	NM_001243733.1	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VEGFB ( NM_001243733.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230662.1 Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.

Price & Availability↑

CloneID	OHu07719
Clone ID Related Accession (Same CDS sequence)	NM_001243733.1 , NM_001243733.2
Accession Version	NM_001243733.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor B isoform VEGFB-167 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6, U48801.1, BG031449.1, BM694361.1 and BU730521.1. Transcript Variant: This variant (VEGFB-167) lacks a segment in the 3' coding region, resulting in a downstream stop codon, compared to variant VEGFB-186. The resulting isoform (VEGFB-167, also known as VRF167) has a shorter and distinct C-terminus, compared to isoform VEGFB-186. This isoform contains the heparin binding domain and is mostly sequestered in the extracellular matrix. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.214636.1, SRR1163658.417338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG CCCCAGGCCC 
CTCTGCCCAC GCTGCACCCA GCACCACCAG CGCCCTGACC CCCGGACCTG CCGCTGCCGC 
TGCCGACGCC GCAGCTTCCT CCGTTGCCAA GGGCGGGGCT TAGAGCTCAA CCCAGACACC 
TGCAGGTGCC GGAAGCTGCG AAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230662.1
CDS	251..817
Translation	MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDSPRPLCPRCTQHHQRPDPRTCRCRCRRRSFLRCQGRGLELNPDTCRCRKLRR

Target ORF information:

RefSeq Version	NM_001243733.1
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243733.1

ORF Insert Sequence:

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG CCCCAGGCCC 
CTCTGCCCAC GCTGCACCCA GCACCACCAG CGCCCTGACC CCCGGACCTG CCGCTGCCGC 
TGCCGACGCC GCAGCTTCCT CCGTTGCCAA GGGCGGGGCT TAGAGCTCAA CCCAGACACC 
TGCAGGTGCC GGAAGCTGCG AAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VEGFB ( NM_001243733.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230662.1 Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.

Price & Availability↑

CloneID	OHu07719
Clone ID Related Accession (Same CDS sequence)	NM_001243733.1 , NM_001243733.2
Accession Version	NM_001243733.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor B isoform VEGFB-167 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6, U48801.1, BG031449.1, BM694361.1 and BU730521.1. On Jun 2, 2019 this sequence version replaced NM_001243733.1. Transcript Variant: This variant (VEGFB-167) lacks a segment in the 3' coding region, resulting in a downstream stop codon, compared to variant VEGFB-186. The resulting isoform (VEGFB-167, also known as VRF167) has a shorter and distinct C-terminus, compared to isoform VEGFB-186. This isoform contains the heparin binding domain and is mostly sequestered in the extracellular matrix. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138527.131272.1, DRR138527.744167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END##

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG CCCCAGGCCC 
CTCTGCCCAC GCTGCACCCA GCACCACCAG CGCCCTGACC CCCGGACCTG CCGCTGCCGC 
TGCCGACGCC GCAGCTTCCT CCGTTGCCAA GGGCGGGGCT TAGAGCTCAA CCCAGACACC 
TGCAGGTGCC GGAAGCTGCG AAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230662.1
CDS	251..817
Translation	MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDSPRPLCPRCTQHHQRPDPRTCRCRCRRRSFLRCQGRGLELNPDTCRCRKLRR

Target ORF information:

RefSeq Version	NM_001243733.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-167, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243733.2

ORF Insert Sequence:

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG CCCCAGGCCC 
CTCTGCCCAC GCTGCACCCA GCACCACCAG CGCCCTGACC CCCGGACCTG CCGCTGCCGC 
TGCCGACGCC GCAGCTTCCT CCGTTGCCAA GGGCGGGGCT TAGAGCTCAA CCCAGACACC 
TGCAGGTGCC GGAAGCTGCG AAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VEGFB ( NM_003377.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003368.1 Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.

Price & Availability↑

CloneID	OHu21835
Clone ID Related Accession (Same CDS sequence)	NM_003377.5 , NM_003377.4
Accession Version	NM_003377.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor B isoform VEGFB-186 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6, BC008818.2, BM694361.1 and BU730521.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_003377.4. Transcript Variant: This variant (VEGFB-186) encodes the longer isoform (VEGFB-186, also known as VRF186). This isoform lacks the heparin binding domain and is secreted freely from cells. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.169474.1, BC008818.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG GGCTGCCACT 
CCCCACCACC GTCCCCAGCC CCGTTCTGTT CCGGGCTGGG ACTCTGCCCC CGGAGCACCC 
TCCCCAGCTG ACATCACCCA TCCCACTCCA GCCCCAGGCC CCTCTGCCCA CGCTGCACCC 
AGCACCACCA GCGCCCTGAC CCCCGGACCT GCCGCTGCCG CTGCCGACGC CGCAGCTTCC 
TCCGTTGCCA AGGGCGGGGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003368.1
CDS	251..874
Translation	MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

Target ORF information:

RefSeq Version	NM_003377.5
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003377.5

ORF Insert Sequence:

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG GGCTGCCACT 
CCCCACCACC GTCCCCAGCC CCGTTCTGTT CCGGGCTGGG ACTCTGCCCC CGGAGCACCC 
TCCCCAGCTG ACATCACCCA TCCCACTCCA GCCCCAGGCC CCTCTGCCCA CGCTGCACCC 
AGCACCACCA GCGCCCTGAC CCCCGGACCT GCCGCTGCCG CTGCCGACGC CGCAGCTTCC 
TCCGTTGCCA AGGGCGGGGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VEGFB ( NM_003377.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003368.1 Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.

Price & Availability↑

CloneID	OHu21835
Clone ID Related Accession (Same CDS sequence)	NM_003377.5 , NM_003377.4
Accession Version	NM_003377.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor B isoform VEGFB-186 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001453.6, BC008818.2, BM694361.1 and BU730521.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2011 this sequence version replaced NM_003377.3. Transcript Variant: This variant (VEGFB-186) encodes the longer isoform (VEGFB-186, also known as VRF186). This isoform lacks the heparin binding domain and is secreted freely from cells. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.171204.1, SRR1163657.522196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG GGCTGCCACT 
CCCCACCACC GTCCCCAGCC CCGTTCTGTT CCGGGCTGGG ACTCTGCCCC CGGAGCACCC 
TCCCCAGCTG ACATCACCCA TCCCACTCCA GCCCCAGGCC CCTCTGCCCA CGCTGCACCC 
AGCACCACCA GCGCCCTGAC CCCCGGACCT GCCGCTGCCG CTGCCGACGC CGCAGCTTCC 
TCCGTTGCCA AGGGCGGGGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003368.1
CDS	251..874
Translation	MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA

Target ORF information:

RefSeq Version	NM_003377.4
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003377.4

ORF Insert Sequence:

ATGAGCCCTC TGCTCCGCCG CCTGCTGCTC GCCGCACTCC TGCAGCTGGC CCCCGCCCAG 
GCCCCTGTCT CCCAGCCTGA TGCCCCTGGC CACCAGAGGA AAGTGGTGTC ATGGATAGAT 
GTGTATACTC GCGCTACCTG CCAGCCCCGG GAGGTGGTGG TGCCCTTGAC TGTGGAGCTC 
ATGGGCACCG TGGCCAAACA GCTGGTGCCC AGCTGCGTGA CTGTGCAGCG CTGTGGTGGC 
TGCTGCCCTG ACGATGGCCT GGAGTGTGTG CCCACTGGGC AGCACCAAGT CCGGATGCAG 
ATCCTCATGA TCCGGTACCC GAGCAGTCAG CTGGGGGAGA TGTCCCTGGA AGAACACAGC 
CAGTGTGAAT GCAGACCTAA AAAAAAGGAC AGTGCTGTGA AGCCAGACAG GGCTGCCACT 
CCCCACCACC GTCCCCAGCC CCGTTCTGTT CCGGGCTGGG ACTCTGCCCC CGGAGCACCC 
TCCCCAGCTG ACATCACCCA TCCCACTCCA GCCCCAGGCC CCTCTGCCCA CGCTGCACCC 
AGCACCACCA GCGCCCTGAC CCCCGGACCT GCCGCTGCCG CTGCCGACGC CGCAGCTTCC 
TCCGTTGCCA AGGGCGGGGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of ?-cell.
Journal of endocrinological investigation40(11)1219-1226(2017 Nov)
Wu J,Wei H,Qu H,Feng Z,Long J,Ge Q,Deng H

The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence.
Bioscience reports37(4)(2017 Aug)
Zafar MI,Zheng J,Kong W,Ye X,Gou L,Regmi A,Chen LL

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.
Cell metabolism25(3)713-726(2017 Mar)
Falkevall A,Mehlem A,Palombo I,Heller Sahlgren B,Ebarasi L,He L,Ytterberg AJ,Olauson H,Axelsson J,Sundelin B,Patrakka J,Scotney P,Nash A,Eriksson U

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VEGFB cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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