azin1b cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	azin1b
Entrez Gene ID	317764
Full Name	antizyme inhibitor 1b
Synonyms	azin1,oazin,wu:fj32d12
General protein information	Preferred Names antizyme inhibitor 1b Names antizyme inhibitor 1b antizyme inhibitor 1 ornithine decarboxylase antizyme inhibitor
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes one of two copies of antizyme inhibitor 1 in zebrafish. It is expressed in embryos and adult fish and may have a role in zebrafish development. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007159.2	NP_001007160.2	antizyme inhibitor 1b

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AZIN1	XP_849306.1
Gallus gallus (chicken)	AZIN1	NP_001008729.1
Pan troglodytes (chimpanzee)	AZIN1	XP_519894.2
	AZIN1	XP_001082807.1
Rattus norvegicus (Norway rat)	Azin1	NP_072107.1
Danio rerio (zebrafish)	azin1b	NP_001007160.1
Homo sapiens (human)	AZIN1	NP_680479.1
Bos taurus (cattle)	AZIN1	NP_001076080.1
Mus musculus (house mouse)	Azin1	NP_001095928.1
Xenopus tropicalis (tropical clawed frog)	azin1	NP_001007944.1

Gene Ontology
Bibliography

Related articles in PubMed

Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate.
Cambier S, R?geberg M, Georgantzopoulou A, Serchi T, Karlsson C, Verhaegen S, Iversen TG, Guignard C, Kruszewski M, Hoffmann L, Audinot JN, Ropstad E, Gutleb AC
The Science of the total environment610-611972-982(2018 Jan)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates.
Kassahn KS, Dang VT, Wilkins SJ, Perkins AC, Ragan MA
Genome research19(8)1404-18(2009 Aug)

Positive correlation between gene coexpression and positional clustering in the zebrafish genome.
Ng YK, Wu W, Zhang L
BMC genomics1042(2009 Jan)

Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone.
Hoffmann JL, Thomason RG, Lee DM, Brill JL, Price BB, Carr GJ, Versteeg DJ
Aquatic toxicology (Amsterdam, Netherlands)87(2)69-80(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following azin1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the azin1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01854	NM_001007159.2 Latest version!	Danio rerio antizyme inhibitor 1b (azin1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

azin1b ( NM_001007159.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001007160.2 Danio rerio antizyme inhibitor 1b (azin1b), mRNA.

Price & Availability↑

CloneID	ODa01854
Clone ID Related Accession (Same CDS sequence)	NM_001007159.2
Accession Version	NM_001007159.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-04-04
Organism	Danio rerio(zebrafish)
Product	antizyme inhibitor 1b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH554389.1, AL807244.7, EH575502.1 and BI884235.1. On or before May 16, 2014 this sequence version replaced XM_005159595.1, NM_001007159.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: GFIL01002090.1, GDQH01003846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAGGAT TCGTTGATGC ACCAAACTAC TTCATTGAAC TACTTGAGGG AGGAACGACC 
CTTGAAAATG TTATTGACAA CCACATATAT GAACAAAATC TGGCTGAAAA GAATGCATTT 
GTTGTGGCCG ACCTTGGGGC CCTAATGCGA CAGCATGTTG TCTGGAAAAC CACCATGCCT 
CTCGTTCGAC CCTTTTACCC AGTCAGTTGT AACAGCAGCC CTGTAGTCAT TGAGCTCCTG 
TCTGCACTTG GTGTGGGATT TGTCTGTGCA AATAAGGCCG AAACTACATT GGTACTTAGT 
CATGATGTCC CTCCTGAGAA CATCATTCTG TCTGGAGTTT GCAAGCAGCT ATCACTCATA 
AAACATGCAG CTAAGACTGG CATTAATTTT TTGTTGTGTG AAAATGAGGC AGAGCTTCGA 
AAAATTGCCC GTGCACATCC TGAGGCTAAG CTTCTGCTTC AAGTGTCTAC TGAAGCACAG 
ATTGAAGAGG CGAGTGTGAC CATCGGTTGC TCACTGAAGG GCTGTAGACA CCTTCTGGAA 
TTGGCCAAGG AGTTGAATGT CAGTGTGGCT GGAGTCACGT TCCAGGTACC AGCATCATGC 
AAAGATCCCC AAGCATACAC CCATGCACTT TCAGATGCCC GCTGCATCTT TGACATGGGG 
AAGGAATTAG GCTTTGACAT GAACATCCTG GATATTGGTG GAGGATTCAG TGGTTCAGAG 
TTTCAGCTGA AACAGGTACA TTCGGTCATC AGGCCCTTGC TGGAGGCTTA TTTCCCCTCA 
GAATCTGGAG TGAGCATCAT TGCTGAACCA GGAAATTTCT TTGTGTTTTC CTGTTTCACC 
CTGGCTGTCA ATGTTATTGG CAAAAAAGCA GCATACCGGA ATCTCCATAC CAGCACTCAC 
GATAAGCTGA CATCTAGCGA CGCACCAGAA TTTGTGTATT ACATGAACGA TGGTGTTTAT 
GGATCTTTCA TGGGGAGGCT GTTCGGAAAT ATCATCTCCA CTCCTTCTGT CCACAAGATG 
TCGCTCACCC TAGATGAGCC AGTGTTCTCC AGCAGCTTGT GGGGCCCATC GTGTGACCCA 
CTGGACCAGG TGGTGGAGCG TTGCCTTCTC CCAGAGCTCG CTGTTGGGGA CTGGCTCGTT 
TTCAGCAACA TGGGGGCAAG CGGTCAGGAA GGGCCAGCAA CCTTCAGCGA CACAGACCAA 
CCACCTGTGT ATTACACCAT CTCCACAGAT GACTGGTTTG AGATGCAAGA GGCTGGAATT 
TCTCTTGACG ACACCATGAA AAACCTCTCA TTGGTCCAGT TTGGCCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007160.2
CDS	367..1677
Translation	MKGFVDAPNYFIELLEGGTTLENVIDNHIYEQNLAEKNAFVVADLGALMRQHVVWKTTMPLVRPFYPVSCNSSPVVIELLSALGVGFVCANKAETTLVLSHDVPPENIILSGVCKQLSLIKHAAKTGINFLLCENEAELRKIARAHPEAKLLLQVSTEAQIEEASVTIGCSLKGCRHLLELAKELNVSVAGVTFQVPASCKDPQAYTHALSDARCIFDMGKELGFDMNILDIGGGFSGSEFQLKQVHSVIRPLLEAYFPSESGVSIIAEPGNFFVFSCFTLAVNVIGKKAAYRNLHTSTHDKLTSSDAPEFVYYMNDGVYGSFMGRLFGNIISTPSVHKMSLTLDEPVFSSSLWGPSCDPLDQVVERCLLPELAVGDWLVFSNMGASGQEGPATFSDTDQPPVYYTISTDDWFEMQEAGISLDDTMKNLSLVQFGL

Target ORF information:

RefSeq Version	NM_001007159.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio antizyme inhibitor 1b (azin1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007159.2

ORF Insert Sequence:

ATGAAAGGAT TCGTTGATGC ACCAAACTAC TTCATTGAAC TACTTGAGGG AGGAACGACC 
CTTGAAAATG TTATTGACAA CCACATATAT GAACAAAATC TGGCTGAAAA GAATGCATTT 
GTTGTGGCCG ACCTTGGGGC CCTAATGCGA CAGCATGTTG TCTGGAAAAC CACCATGCCT 
CTCGTTCGAC CCTTTTACCC AGTCAGTTGT AACAGCAGCC CTGTAGTCAT TGAGCTCCTG 
TCTGCACTTG GTGTGGGATT TGTCTGTGCA AATAAGGCCG AAACTACATT GGTACTTAGT 
CATGATGTCC CTCCTGAGAA CATCATTCTG TCTGGAGTTT GCAAGCAGCT ATCACTCATA 
AAACATGCAG CTAAGACTGG CATTAATTTT TTGTTGTGTG AAAATGAGGC AGAGCTTCGA 
AAAATTGCCC GTGCACATCC TGAGGCTAAG CTTCTGCTTC AAGTGTCTAC TGAAGCACAG 
ATTGAAGAGG CGAGTGTGAC CATCGGTTGC TCACTGAAGG GCTGTAGACA CCTTCTGGAA 
TTGGCCAAGG AGTTGAATGT CAGTGTGGCT GGAGTCACGT TCCAGGTACC AGCATCATGC 
AAAGATCCCC AAGCATACAC CCATGCACTT TCAGATGCCC GCTGCATCTT TGACATGGGG 
AAGGAATTAG GCTTTGACAT GAACATCCTG GATATTGGTG GAGGATTCAG TGGTTCAGAG 
TTTCAGCTGA AACAGGTACA TTCGGTCATC AGGCCCTTGC TGGAGGCTTA TTTCCCCTCA 
GAATCTGGAG TGAGCATCAT TGCTGAACCA GGAAATTTCT TTGTGTTTTC CTGTTTCACC 
CTGGCTGTCA ATGTTATTGG CAAAAAAGCA GCATACCGGA ATCTCCATAC CAGCACTCAC 
GATAAGCTGA CATCTAGCGA CGCACCAGAA TTTGTGTATT ACATGAACGA TGGTGTTTAT 
GGATCTTTCA TGGGGAGGCT GTTCGGAAAT ATCATCTCCA CTCCTTCTGT CCACAAGATG 
TCGCTCACCC TAGATGAGCC AGTGTTCTCC AGCAGCTTGT GGGGCCCATC GTGTGACCCA 
CTGGACCAGG TGGTGGAGCG TTGCCTTCTC CCAGAGCTCG CTGTTGGGGA CTGGCTCGTT 
TTCAGCAACA TGGGGGCAAG CGGTCAGGAA GGGCCAGCAA CCTTCAGCGA CACAGACCAA 
CCACCTGTGT ATTACACCAT CTCCACAGAT GACTGGTTTG AGATGCAAGA GGCTGGAATT 
TCTCTTGACG ACACCATGAA AAACCTCTCA TTGGTCCAGT TTGGCCTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate.
The Science of the total environment610-611972-982(2018 Jan)
Cambier S,R?geberg M,Georgantzopoulou A,Serchi T,Karlsson C,Verhaegen S,Iversen TG,Guignard C,Kruszewski M,Hoffmann L,Audinot JN,Ropstad E,Gutleb AC

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates.
Genome research19(8)1404-18(2009 Aug)
Kassahn KS,Dang VT,Wilkins SJ,Perkins AC,Ragan MA

Positive correlation between gene coexpression and positional clustering in the zebrafish genome.
BMC genomics1042(2009 Jan)
Ng YK,Wu W,Zhang L

Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone.
Aquatic toxicology (Amsterdam, Netherlands)87(2)69-80(2008 Apr)
Hoffmann JL,Thomason RG,Lee DM,Brill JL,Price BB,Carr GJ,Versteeg DJ

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azin1b cDNA ORF clone, Danio rerio(zebrafish)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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