ELOB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELOB
Entrez Gene ID	6923
Full Name	elongin B
Synonyms	SIII,TCEB2
General protein information	Preferred Names elongin B Names elongin-B RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II transcription factor SIII subunit B SIII p18 elongin 18 kDa subunit elongin, 18-kD subunit transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) transcription elongation factor B polypeptide 2 transcription elongation factor B subunit 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008].
Disorder MIM:	600787

mRNA and Protein(s)

mRNA	Protein	Name
NM_207013.2	NP_996896.1	elongin-B isoform b
NM_007108.3	NP_009039.1	elongin-B isoform a
NM_207013.3	NP_996896.1	elongin-B isoform b
NM_007108.4	NP_009039.1	elongin-B isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	TCEB2	NP_996896.1
Pan troglodytes (chimpanzee)	TCEB2	XP_001173192.1
Bos taurus (cattle)	TCEB2	NP_001029972.1
Rattus norvegicus (Norway rat)	LOC100909963	XP_006242543.1
	TCEB2	XP_001113620.1
Canis lupus familiaris (dog)	LOC479873	XP_536998.2

Gene Ontology
Bibliography

Related articles in PubMed

TCEB2 confers resistance to VEGF-targeted therapy in ovarian cancer.
Deng Z, Zhou J, Han X, Li X
Oncology reports35(1)359-65(2016 Jan)

Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.
Nguyen HC, Yang H, Fribourgh JL, Wolfe LS, Xiong Y
Structure (London, England : 1993)23(3)441-9(2015 Mar)

Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.
Gadd MS, Bulatov E, Ciulli A
PloS one10(6)e0131218(2015)

Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-? binding to Vif.
Wang X, Wang X, Zhang H, Lv M, Zuo T, Wu H, Wang J, Liu D, Wang C, Zhang J, Li X, Wu J, Yu B, Kong W, Yu X
Retrovirology1094(2013 Aug)

Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
Thomas JC, Matak-Vinkovic D, Van Molle I, Ciulli A
Biochemistry52(31)5236-46(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that TCEB2 is involved in the development of acquired resistance to bevacizumab in ovarian cancer cells via the mechanisms of suppression of VEGF-A expression by promoting HIF-1alpha degradation and induction of interleukin-8 (IL-8) expression.
Title: TCEB2 confers resistance to VEGF-targeted therapy in ovarian cancer.

The crystal structure of VHL bound to a Cul2 N-terminal domain, Elongin B, and Elongin C.
Title: Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.

crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.
Title: Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.

Vif interaction with EloB-EloC may contribute to recruitment of CBF-beta to Vif, demonstrating that the EloB C-teminus may play a role in improving Vif function and that the over-expression of EloB results in Vif stabilization.
Title: Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-? binding to Vif.

ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain.
Title: Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.

The following ELOB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELOB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00800	NM_007108.4 Latest version!	Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01701	NM_207013.3 Latest version!	Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01701	NM_207013.2	Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00800	NM_007108.3	Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELOB ( NM_007108.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009039.1 Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00800
Clone ID Related Accession (Same CDS sequence)	NM_007108.3 , NM_007108.4
Accession Version	NM_007108.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	elongin-B isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092117.4, BC013306.2 and DT217333.1. On Aug 2, 2011 this sequence version replaced NM_007108.2. Transcript Variant: This variant (1) encodes the predominant isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM553320.1, BG700495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009039.1
CDS	58..414
Translation	MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ

Target ORF information:

RefSeq Version	NM_007108.3
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007108.3

ORF Insert Sequence:

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOB ( NM_007108.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009039.1 Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00800
Clone ID Related Accession (Same CDS sequence)	NM_007108.3 , NM_007108.4
Accession Version	NM_007108.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	elongin-B isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092117.4, BC013306.2 and DT217333.1. On Jun 2, 2019 this sequence version replaced NM_007108.3. Transcript Variant: This variant (1) encodes the predominant isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.53580.1, BC013306.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009039.1
CDS	42..398
Translation	MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ

Target ORF information:

RefSeq Version	NM_007108.4
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin B (ELOB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007108.4

ORF Insert Sequence:

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOB ( NM_207013.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_996896.1 Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01701
Clone ID Related Accession (Same CDS sequence)	NM_207013.2 , NM_207013.3
Accession Version	NM_207013.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	elongin-B isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092117.4, BM700019.1 and BC013306.2. On Aug 3, 2011 this sequence version replaced NM_207013.1. Transcript Variant: This variant (2) lacks a segment in the 3' region, resulting in a downstream stop codon, compared to variant 1. The resulting isoform (b) has a longer C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM700019.1, HY188936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMN03267781 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCACCTGCAT 
GTCCACTCCC AGACGATGGC CAAGAGCAGA AACACAAGCT GGAGCCAGTG TCCTGGTTTG 
ACAGCATGTT CAACGAGGGA ACCCCAAGAC GGACCCACAC AGGTCCACCC ACGCTGGGGG 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996896.1
CDS	58..543
Translation	MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVHLHVHSQTMAKSRNTSWSQCPGLTACSTREPQDGPTQVHPRWGL

Target ORF information:

RefSeq Version	NM_207013.2
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207013.2

ORF Insert Sequence:

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCACCTGCAT 
GTCCACTCCC AGACGATGGC CAAGAGCAGA AACACAAGCT GGAGCCAGTG TCCTGGTTTG 
ACAGCATGTT CAACGAGGGA ACCCCAAGAC GGACCCACAC AGGTCCACCC ACGCTGGGGG 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ELOB ( NM_207013.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_996896.1 Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01701
Clone ID Related Accession (Same CDS sequence)	NM_207013.2 , NM_207013.3
Accession Version	NM_207013.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	elongin-B isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092117.4, BM700019.1 and BC013306.2. On Jun 2, 2019 this sequence version replaced NM_207013.2. Transcript Variant: This variant (2) lacks a segment in the 3' region, resulting in a downstream stop codon, compared to variant 1. The resulting isoform (b) has a longer C-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM700019.1, HY188936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMN03267781 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCACCTGCAT 
GTCCACTCCC AGACGATGGC CAAGAGCAGA AACACAAGCT GGAGCCAGTG TCCTGGTTTG 
ACAGCATGTT CAACGAGGGA ACCCCAAGAC GGACCCACAC AGGTCCACCC ACGCTGGGGG 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996896.1
CDS	42..527
Translation	MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVHLHVHSQTMAKSRNTSWSQCPGLTACSTREPQDGPTQVHPRWGL

Target ORF information:

RefSeq Version	NM_207013.3
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin B (ELOB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207013.3

ORF Insert Sequence:

ATGGACGTGT TCCTCATGAT CCGGCGCCAC AAGACCACCA TCTTCACGGA CGCCAAGGAG 
TCCAGCACGG TGTTCGAACT GAAGCGCATC GTCGAGGGCA TCCTCAAGCG GCCTCCTGAC 
GAGCAGCGGC TGTACAAGGA TGACCAACTC TTGGATGATG GCAAGACACT GGGCGAGTGT 
GGCTTCACCA GTCAAACAGC ACGGCCACAG GCCCCAGCCA CAGTGGGGCT GGCCTTCCGG 
GCAGATGACA CCTTTGAGGC CCTGTGCATC GAGCCGTTTT CCAGCCCGCC AGAGCTGCCC 
GATGTGATGA AGCCCCAGGA CTCGGGAAGC AGTGCCAATG AACAAGCCGT GCACCTGCAT 
GTCCACTCCC AGACGATGGC CAAGAGCAGA AACACAAGCT GGAGCCAGTG TCCTGGTTTG 
ACAGCATGTT CAACGAGGGA ACCCCAAGAC GGACCCACAC AGGTCCACCC ACGCTGGGGG 
CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TCEB2 confers resistance to VEGF-targeted therapy in ovarian cancer.
Oncology reports35(1)359-65(2016 Jan)
Deng Z,Zhou J,Han X,Li X

Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.
Structure (London, England : 1993)23(3)441-9(2015 Mar)
Nguyen HC,Yang H,Fribourgh JL,Wolfe LS,Xiong Y

Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.
PloS one10(6)e0131218(2015)
Gadd MS,Bulatov E,Ciulli A

Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-? binding to Vif.
Retrovirology1094(2013 Aug)
Wang X,Wang X,Zhang H,Lv M,Zuo T,Wu H,Wang J,Liu D,Wang C,Zhang J,Li X,Wu J,Yu B,Kong W,Yu X

Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
Biochemistry52(31)5236-46(2013 Aug)
Thomas JC,Matak-Vinkovic D,Van Molle I,Ciulli A

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ELOB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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